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From GWAS to Next-Generation Sequencing on Human Complex Diseases: The Implications for Translational Medicine and Therapeutics

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Applied Computational Genomics

Part of the book series: Translational Bioinformatics ((TRBIO,volume 1))

Abstract

Because the genetic architecture of human complex disease remains elusive, the clinical application of current genetic knowledge remains a formidable challenge. The field of translational genomics is rapidly progressing with the development of next-generation sequencing (NGS) technologies. NGS is poised to produce a sea change in clinical practice by providing new insights into our understanding of complex human diseases. In this review, we will discuss a broad range of issues on how NGS will transform current genetic research especially in the areas of cancer and mental health.

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  1. Unit of Statistical Genomics, Division of Intramural Research Programs, National Institute of Mental Health (NIMH)/NIH, Building 35; Room 3A-1006, Bethesda, MD, USA

    Hai-De Qin

  2. Department of Medicine, Johns Hopkins University, 600 North Wolfe Street, Blalock Building, Room 1033, Baltimore, MD, USA

    Alan Scott

  3. Unit of Statistical Genomics, Intramural Research, Program, National Institute of Mental Health, 35 Convent Drive, Room 3A1000, Bethesda, MD, 20892-3719, USA

    Harold Z. Wang & Yin Yao Shugart

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Qin, HD., Scott, A., Wang, H.Z., Shugart, Y.Y. (2012). From GWAS to Next-Generation Sequencing on Human Complex Diseases: The Implications for Translational Medicine and Therapeutics. In: Shugart, Y. (eds) Applied Computational Genomics. Translational Bioinformatics, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-5558-1_10

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