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Primary Central Nervous System Lymphoma Resulting in Stroke and Leukoencephalopathy

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Tumors of the Central Nervous System, Volume 9

Part of the book series: Tumors of the Central Nervous System ((TCNS,volume 9))

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Abstract

In rare instances primary CNS lymphoma (PCNSL) manifests as an intravascular tumour or shows a diffuse infiltrating phenotype known as “lymphomatosis cerebri”. Intravascular PCNSL presents with multiple cerebral infarcts caused by the occlusion of small- to medium-sized vessels while diffuse infiltrating PCNSL is characterized by progressive white matter lesions translating into behavioural changes and cognitive decline. We describe the clinical and histological peculiarities, key imaging findings, diagnostic challenges and differential diagnoses of these special types of PCNSL, and provide a review of literature cases. Prognosis is generally worse than that of classic PCNSL and critically depends on an early diagnosis.

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Authors and Affiliations

  1. Department of Neurology, Medical University Innsbruck, Innsbruck, Austria

    Stefan Kiechl, Benjamin Matosevic & Johann Willeit

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  1. Stefan Kiechl
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  2. Benjamin Matosevic
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  3. Johann Willeit
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Correspondence to Stefan Kiechl .

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  1. , Kean University, Room 213, Library building, Morris Avenue 1000, Union, 07083, New Jersey, USA

    M.A. Hayat

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Kiechl, S., Matosevic, B., Willeit, J. (2012). Primary Central Nervous System Lymphoma Resulting in Stroke and Leukoencephalopathy. In: Hayat, M. (eds) Tumors of the Central Nervous System, Volume 9. Tumors of the Central Nervous System, vol 9. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-5488-1_4

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  • DOI: https://doi.org/10.1007/978-94-007-5488-1_4

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