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Tumors of the Central Nervous System, Volume 9 pp 177–183Cite as

Proliferation of Neuroblasts in the Adult Brain: Role of Diversin

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Part of the book series: Tumors of the Central Nervous System ((TCNS,volume 9))

Abstract

The subventricular zone (SVZ) is the largest neurogenic region in the adult rodent brain. In this region, new neurons that originate from neural stem cells (NSCs) migrate to the olfactory bulb, where they mature into interneurons. During neurogenesis, the proliferation of NSCs and neuronal progenitor cells are precisely regulated by multiple signaling pathways to maintain homeostasis. Wnt signaling is one mechanism that controls the proliferation of SVZ cells. In addition to NSCs and progenitor cells, the migration of new neurons (neuroblasts) also maintains the proliferative capacity. Recently, Diversin, which is a component of the Wnt signaling pathway, has been shown to promote the proliferation of neuroblasts in the SVZ. Neuroblast proliferation may be an important step in regenerative responses to brain injury and in normal physio­logical neurogenesis.

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Authors and Affiliations

  1. Department of Developmental and Regenerative Biology, Nagoya City University Graduate School of Medical Sciences, Mizuho-cho, Mizuho-ku, Nagoya, 467-8601, Japan

    Yuki Hirota & Kazunobu Sawamoto

Authors
  1. Yuki Hirota
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  2. Kazunobu Sawamoto
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Correspondence to Kazunobu Sawamoto .

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Editors and Affiliations

  1. , Kean University, Room 213, Library building, Morris Avenue 1000, Union, 07083, New Jersey, USA

    M.A. Hayat

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Hirota, Y., Sawamoto, K. (2012). Proliferation of Neuroblasts in the Adult Brain: Role of Diversin. In: Hayat, M. (eds) Tumors of the Central Nervous System, Volume 9. Tumors of the Central Nervous System, vol 9. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-5488-1_20

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  • DOI: https://doi.org/10.1007/978-94-007-5488-1_20

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  • Online ISBN: 978-94-007-5488-1

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