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Hemodynamic Alterations Associated with Coronary and Cerebral Arterial Remodeling Following a Surgically-Induced Aortic Coarctation

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Computer Models in Biomechanics

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Abstract

Computational models promise to aid in the interpretation of the coupled interactions between evolving wall geometry, structure, material properties and hemodynamics seen in arterial adaptations. Motivated by recent aortic coarctation models in animals, we used a computational fluid-solid-interaction model to study possible local and systemic effects on the hemodynamics within the thoracic aorta and coronary, carotid, and cerebral arteries due to a distal aortic coarctation and subsequent spatial variations in wall adaptation. In particular, we studied an initial stage of acute cardiac compensation (maintenance of cardiac output) followed by early arterial wall remodeling (spatially varying wall thickening and stiffening).

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Acknowledgements

This work was supported by NIH grant HL-105297, the Benchmark Fellowship in Congenital Cardiovascular Engineering and the Vera Moulton Wall Center at Stanford University.

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Authors and Affiliations

  1. King’s College London, London, SE16 7EH, UK

    C. Alberto Figueroa

  2. Stanford University, Stanford, CA, 94305, USA

    Jessica S. Coogan

  3. Department of Biomedical Engineering, Yale University, New Haven, CT, 06520, USA

    Jay D. Humphrey

Authors
  1. C. Alberto Figueroa
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  2. Jessica S. Coogan
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  3. Jay D. Humphrey
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Corresponding author

Correspondence to C. Alberto Figueroa .

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Editors and Affiliations

  1. Institute of Biomechanics, Center of Biomedical Engineering, Graz University of Technology, Kronegasse 5-I, Graz, 8010, Austria

    Gerhard A. Holzapfel

  2. Dept. Mechanical Engineering, Dept. of Bioengineering (courtesy), Stanford University, Lomita Mall 496, Stanford, 94305-4040, California, USA

    Ellen Kuhl

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Figueroa, C.A., Coogan, J.S., Humphrey, J.D. (2013). Hemodynamic Alterations Associated with Coronary and Cerebral Arterial Remodeling Following a Surgically-Induced Aortic Coarctation. In: Holzapfel, G., Kuhl, E. (eds) Computer Models in Biomechanics. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-5464-5_15

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  • DOI: https://doi.org/10.1007/978-94-007-5464-5_15

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-007-5463-8

  • Online ISBN: 978-94-007-5464-5

  • eBook Packages: EngineeringEngineering (R0)

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