Skip to main content
SpringerLink
Log in

Malignant Diseases Associated with Human Papillomavirus Infection

  • Chapter
  • First Online:
HPV and Cancer

  • 1952 Accesses

Abstract

This chapter summarizes current knowledge on the contribution of the human papillomavirus (HPV) to the etiology of cancer. An etiological link between HPV infection and cancer at particular anatomical sites is reviewed. Those sites are the uterine cervix, the penis, the head and neck and the anus. For each site, the epidemiology, clinical features, diagnosis, treatment, and prognosis are examined. Finally, recent progress in the developments, approval, and clinical implementation of vaccines targeting HPV is reviewed.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Abbreviations

HPV:

Human Papillomavirus

CIN:

Intraepithelial Neoplasia

CIS:

Carcinoma In-situ

WHO/ICO:

World Health Organization/Institut Catala d' Oncologia

MRI:

Magnetic Resonance Imaging

CT:

Computed Tomography

PCR:

Polymerase Chain Reaction

ISH:

In-situ Hybridization

IMRT:

Intensity Modulated Radiation Therapy

PET:

Positron Emission Tomography

5-FU:

5-Fluorouracil

HAART:

Highly Active Anti-Retroviral Treatment

CIN:

Cervical Intra-epithelial Neoplasm

VaIN:

Vaginal Intra-epithelial Neoplasm

FDA:

Food & Drug Administration

References

  • Reid, R., C. R. Stanhope, B. R. Herschman, E. Booth, G. D. Phibbs, and J. P. Smith. 1982. Genital warts and cervical cancer. I. Evidence of an association between subclinical papillomavirus infection and cervical malignancy. Cancer 50:377–387.

    Article  PubMed  CAS  Google Scholar 

  • Roy, M., C. Morin, M. Casas-Cordero, and A. Meisels. 1983. Human papillomavirus and cervical lesions. Clin Obstet Gynecol 26:949–967.

    Article  PubMed  CAS  Google Scholar 

  • Boshart, M., L. Gissmann, H. Ikenberg, A. Kleinheinz, W. Scheurlen, and H. zur Hausen. 1984. A new type of papillomavirus DNA, its presence in genital cancer biopsies and in cell lines derived from cervical cancer. Embo J 3:1151–1157.

    PubMed  CAS  Google Scholar 

  • Yee, C., I. Krishnan-Hewlett, C. C. Baker, R. Schlegel, and P. M. Howley. 1985. Presence and expression of human papillomavirus sequences in human cervical carcinoma cell lines. Am J Pathol 119:361–366.

    PubMed  CAS  Google Scholar 

  • Leung, A. K., J. D. Kellner, and H. D. Davies. 2005. Genital infection with human papillomavirus in adolescents. Adv Ther 22:187–197.

    Article  PubMed  Google Scholar 

  • WHO/ICO. 2010. Information Centre on HPV and Cervical Cancer (HPV Information Centre). Human Papillomavirus and Related Cancers in World. Summary Report 2010.

    Google Scholar 

  • Castellsague, X., F. X. Bosch, N. Munoz, C. J. Meijer, K. V. Shah, S. de Sanjose, J. Eluf-Neto, C. A. Ngelangel, S. Chichareon, J. S. Smith, R. Herrero, V. Moreno, and S. Franceschi. 2002. Male circumcision, penile human papillomavirus infection, and cervical cancer in female partners. N Engl J Med 346:1105–1112.

    Article  PubMed  Google Scholar 

  • Warren, J. B., H. Gullett, and V. J. King. 2009. Cervical cancer screening and updated Pap guidelines. Prim Care 36:131–149, ix.

    Google Scholar 

  • US Cancer Statistics Working Group. 2010. United States Cancer Statistics: 1999–2007 Incidence and Mortality Web-based Report. Atlanta: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention and National Cancer Institute. U. C. S. W. Group, ed.

    Google Scholar 

  • Shield, P. W., B. Daunter, and R. G. Wright. 1987. The Pap smear revisited. Aust N Z J Obstet Gynaecol 27:269–283.

    Article  PubMed  CAS  Google Scholar 

  • Celentano, D. D., A. C. Klassen, C. S. Weisman, and N. B. Rosenshein. 1989. Duration of relative protection of screening for cervical cancer. Prev Med 18:411–422.

    Article  PubMed  CAS  Google Scholar 

  • Beal, M. W. 1990. Cervical cytology. NAACOGS Clin Issu Perinat Womens Health Nurs 1:470–478.

    PubMed  CAS  Google Scholar 

  • Grce, M., and P. Davies. 2008. Human papillomavirus testing for primary cervical cancer screening. Expert Rev Mol Diagn 8:599–605.

    Article  PubMed  Google Scholar 

  • Subramanya, D., and P. D. Grivas. 2008. HPV and cervical cancer: updates on an established relationship. Postgrad Med 120:7–13.

    Article  PubMed  Google Scholar 

  • Cuzick, J. 2010. Long-term cervical cancer prevention strategies across the globe. Gynecologic Oncology 117:S11–S14.

    Google Scholar 

  • Spayne, J., I. Ackerman, M. Milosevic, A. Seidenfeld, A. Covens, and L. Paszat. 2008. Invasive cervical cancer: a failure of screening. Eur J Public Health 18:162–165.

    Article  PubMed  Google Scholar 

  • Rosa, D. D., L. R. Medeiros, M. I. Edelweiss, M. C. Bozzetti, P. R. Pohlmann, A. T. Stein, and H. O. Dickinson. 2009. Adjuvant platinum-based chemotherapy for early stage cervical cancer. Cochrane Database Syst Rev:CD005342.

    Google Scholar 

  • Shepherd, J. H. 2009. Challenging dogma: radical conservation surgery for early stage cervical cancer in order to retain fertility. Ann R Coll Surg Engl 91:181–187.

    Article  PubMed  Google Scholar 

  • Sharma, P., M. Rahi, and P. Lal. 2010. A Community-based Cervical Cancer Screening Program among Women of Delhi using Camp Approach. Indian J Community Med 35:86–88.

    Google Scholar 

  • Merck & Co Inc. 2010. The Mercks Manual Online Medical Library.

    Google Scholar 

  • Chaux, A., E. F. Velazquez, F. Algaba, G. Ayala, and A. L. Cubilla. 2010. Developments in the pathology of penile squamous cell carcinomas. Urology 76:S7–S14.

    Article  PubMed  Google Scholar 

  • Guimaraes, G. C., R. M. Rocha, S. C. Zequi, I. W. Cunha, and F. A. Soares. 2011. Penile Cancer: Epidemiology and Treatment. Curr Oncol Rep.

    Google Scholar 

  • Pow-Sang, M. R., U. Ferreira, J. M. Pow-Sang, A. C. Nardi, and V. Destefano. 2010. Epidemiology and natural history of penile cancer. Urology 76:S2–6.

    Article  PubMed  Google Scholar 

  • Miralles-Guri, C., L. Bruni, A. L. Cubilla, X. Castellsague, F. X. Bosch, and S. de Sanjose. 2009. Human papillomavirus prevalence and type distribution in penile carcinoma. J Clin Pathol 62:870–878.

    Article  PubMed  CAS  Google Scholar 

  • Palefsky, J. M. 2010. Human papillomavirus-related disease in men: not just a women’s issue. J Adolesc Health 46:S12–19.

    Article  PubMed  Google Scholar 

  • Backes, D. M., R. J. Kurman, J. M. Pimenta, and J. S. Smith. 2009. Systematic review of human papillomavirus prevalence in invasive penile cancer. Cancer Causes Control 20:449–457.

    Article  PubMed  Google Scholar 

  • Gross, G., and H. Pfister. 2004. Role of human papillomavirus in penile cancer, penile intraepithelial squamous cell neoplasias and in genital warts. Med Microbiol Immunol 193:35–44.

    Article  PubMed  CAS  Google Scholar 

  • Heyns, C. F., A. Mendoza-Valdes, and A. C. Pompeo. 2010. Diagnosis and staging of penile cancer. Urology 76:S15–23.

    Article  PubMed  Google Scholar 

  • Rossari, J. R., T. Vora, and T. Gil. 2010. Advances in penile cancer management. Curr Opin Oncol 22:226–235.

    Article  PubMed  Google Scholar 

  • Solsona, E., A. Bahl, S. B. Brandes, D. Dickerson, A. Puras-Baez, H. van Poppel, and N. A. Watkin. 2010. New developments in the treatment of localized penile cancer. Urology 76:S36–42.

    Article  PubMed  Google Scholar 

  • Delacroix, S. E., Jr., and C. A. Pettaway. 2010. Therapeutic strategies for advanced penile carcinoma. Curr Opin Support Palliat Care 4:285–292.

    Article  PubMed  Google Scholar 

  • Syrjanen, K. J., and S. M. Surjanen. 1981. Histological evidence for the presence of condylomatous epithelial lesions in association with laryngeal squamous cell carcinoma. ORL J Otorhinolaryngol Relat Spec 43:181–194.

    Article  PubMed  CAS  Google Scholar 

  • Jo, V. Y., S. E. Mills, M. H. Stoler, and E. B. Stelow. 2009. Papillary squamous cell carcinoma of the head and neck: frequent association with human papillomavirus infection and invasive carcinoma. Am J Surg Pathol 33:1720–1724.

    Article  PubMed  Google Scholar 

  • Baumann, J. L., S. Cohen, A. N. Evjen, J. H. Law, S. Vadivelu, A. Attia, J. S. Schindler, C. H. Chung, P. S. Wirth, C. J. Meijer, P. J. Snijders, W. G. Yarbrough, and R. J. Slebos. 2009. Human papillomavirus in early laryngeal carcinoma. Laryngoscope 119:1531–1537.

    Article  PubMed  Google Scholar 

  • Balukova, O. V., L. N. Shcherbak, N. A. Savelov, G. V. Ungiadze, and I. B. Zborovskaia. 2004. [Papilloma virus infection in pretumor and tumor masses of the larynx]. Vestn Ross Akad Med Nauk:36–39.

    Google Scholar 

  • Smith, E. M., L. M. Rubenstein, T. H. Haugen, E. Hamsikova, and L. P. Turek. 2010. Tobacco and alcohol use increases the risk of both HPV-associated and HPV-independent head and neck cancers. Cancer Causes Control 21:1369–1378.

    Google Scholar 

  • National Cancer Institute. 2010. SEER Stat Fact Sheets: Oral Cavity and Pharynx.

    Google Scholar 

  • Singhi, A. D., and W. H. Westra. 2010. Comparison of human papillomavirus in situ hybridization and p16 immunohistochemistry in the detection of human papillomavirus-associated head and neck cancer based on a prospective clinical experience. Cancer 116:2166–2173.

    PubMed  Google Scholar 

  • Jacobi, I., L. van der Molen, H. Huiskens, M. A. van Rossum, and F. J. Hilgers. 2010. Voice and speech outcomes of chemoradiation for advanced head and neck cancer: a systematic review. Eur Arch Otorhinolaryngol 267:1495–1505.

    Article  PubMed  Google Scholar 

  • Peponi, E., C. Glanzmann, B. Willi, G. Huber, and G. Studer. 2010. Dysphagia in head and neck cancer patients following intensity modulated radiotherapy (IMRT). Radiat Oncol 6:1.

    Google Scholar 

  • Syrjanen, S. M., K. J. Syrjanen, and M. A. Lamberg. 1986. Detection of human papillomavirus DNA in oral mucosal lesions using in situ DNA-hybridization applied on paraffin sections. Oral Surg Oral Med Oral Pathol 62:660–667.

    Article  PubMed  CAS  Google Scholar 

  • Gillison, M. L., G. D’Souza, W. Westra, E. Sugar, W. Xiao, S. Begum, and R. Viscidi. 2008. Distinct risk factor profiles for human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck cancers. J Natl Cancer Inst 100:407–420.

    Article  PubMed  Google Scholar 

  • Kreimer, A. R., G. M. Clifford, P. Boyle, and S. Franceschi. 2005. Human papillomavirus types in head and neck squamous cell carcinomas worldwide: a systematic review. Cancer Epidemiol Biomarkers Prev 14:467–475.

    Article  PubMed  CAS  Google Scholar 

  • Dayyani, F., C. J. Etzel, M. Liu, C. H. Ho, S. M. Lippman, and A. S. Tsao. 2010. Meta-analysis of the impact of human papillomavirus (HPV) on cancer risk and overall survival in head and neck squamous cell carcinomas (HNSCC). Head Neck Oncol 2:15.

    Article  PubMed  Google Scholar 

  • Campisi, G., and L. Giovannelli. 2009. Controversies surrounding human papilloma virus infection, head & neck vs oral cancer, implications for prophylaxis and treatment. Head Neck Oncol 1:8.

    Article  PubMed  Google Scholar 

  • Giovannelli, L., G. Campisi, A. Lama, O. Giambalvo, J. Osborn, V. Margiotta, and P. Ammatuna. 2002. Human papillomavirus DNA in oral mucosal lesions. J Infect Dis 185:833–836.

    Article  PubMed  CAS  Google Scholar 

  • Terai, M., K. Hashimoto, K. Yoda, and T. Sata. 1999. High prevalence of human papillomaviruses in the normal oral cavity of adults. Oral Microbiol Immunol 14:201–205.

    Article  PubMed  CAS  Google Scholar 

  • Patel, S. C., W. R. Carpenter, S. Tyree, M. E. Couch, M. Weissler, T. Hackman, D. N. Hayes, C. Shores, and B. S. Chera. 2011. Increasing Incidence of Oral Tongue Squamous Cell Carcinoma in Young White Women, Age 18 to 44 Years. J Clin Oncol.

    Google Scholar 

  • Schantz, S. P., and G. P. Yu. 2002. Head and neck cancer incidence trends in young Americans, 1973–1997, with a special analysis for tongue cancer. Arch Otolaryngol Head Neck Surg 128:268–274.

    PubMed  Google Scholar 

  • Shiboski, C. H., B. L. Schmidt, and R. C. Jordan. 2005. Tongue and tonsil carcinoma: increasing trends in the U.S. population ages 20–44 years. Cancer 103:1843–1849.

    Article  PubMed  Google Scholar 

  • Kreimer, A. R., A. J. Alberg, R. Viscidi, and M. L. Gillison. 2004. Gender differences in sexual biomarkers and behaviors associated with human papillomavirus-16, -18, and −33 seroprevalence. Sex Transm Dis 31:247–256.

    Article  PubMed  Google Scholar 

  • D’Souza, G., Y. Agrawal, J. Halpern, S. Bodison, and M. L. Gillison. 2009. Oral sexual behaviors associated with prevalent oral human papillomavirus infection. J Infect Dis 199:1263–1269.

    Article  PubMed  Google Scholar 

  • Angiero, F., L. B. Gatta, R. Seramondi, A. Berenzi, A. Benetti, S. Magistro, P. Ordesi, P. Grigolato, and E. Dessy. 2010. Frequency and role of HPV in the progression of epithelial dysplasia to oral cancer. Anticancer Res 30:3435–3440.

    Google Scholar 

  • Sikora, A. G., L. G. Morris, and E. M. Sturgis. 2009. Bidirectional association of anogenital and oral cavity/pharyngeal carcinomas in men. Arch Otolaryngol Head Neck Surg 135:402–405.

    Article  PubMed  Google Scholar 

  • Saini, R., T. P. Khim, S. A. Rahman, M. Ismail, and T. H. Tang. 2010. High-risk human papillomavirus in the oral cavity of women with cervical cancer, and their children. Virol J 7:131.

    Google Scholar 

  • Silverman S Jr. 2003. Oral Cancer. BC Decker Inc, London.

    Google Scholar 

  • Epstein, J. B., J. Sciubba, S. Silverman, Jr., and H. Y. Sroussi. 2007. Utility of toluidine blue in oral premalignant lesions and squamous cell carcinoma: continuing research and implications for clinical practice. Head Neck 29:948–958.

    Article  PubMed  Google Scholar 

  • Brocklehurst, P., O. Kujan, A. M. Glenny, R. Oliver, P. Sloan, G. Ogden, and S. Shepherd. 2010. Screening programmes for the early detection and prevention of oral cancer. Cochrane Database Syst Rev:CD004150.

    Google Scholar 

  • Guillemaud, J. P., R. S. Patel, D. P. Goldstein, K. M. Higgins, and D. J. Enepekides. 2010. Prognostic impact of intraoperative microscopic cut-through on frozen section in oral cavity squamous cell carcinoma. J Otolaryngol Head Neck Surg 39:370–377.

    PubMed  Google Scholar 

  • Khuri, F. R., E. S. Kim, J. J. Lee, R. J. Winn, S. E. Benner, S. M. Lippman, K. K. Fu, J. S. Cooper, E. E. Vokes, R. M. Chamberlain, B. Williams, T. F. Pajak, H. Goepfert, and W. K. Hong. 2001. The impact of smoking status, disease stage, and index tumor site on second primary tumor incidence and tumor recurrence in the head and neck retinoid chemoprevention trial. Cancer Epidemiol Biomarkers Prev 10:823–829.

    PubMed  CAS  Google Scholar 

  • Vered, M., D. Dayan, A. Dobriyan, R. Yahalom, B. Shalmon, I. Barshack, L. Bedrin, Y. P. Talmi, and S. Taicher. 2010. Oral tongue squamous cell carcinoma: recurrent disease is associated with histopathologic risk score and young age. J Cancer Res Clin Oncol 136:1039–1048.

    Article  PubMed  Google Scholar 

  • American Cancer Society. 2010. Cancer facts and figures 2010.

    Google Scholar 

  • Palefsky, J. 2008. Human papillomavirus and anal neoplasia. Curr HIV/AIDS Rep 5:78–85.

    Article  PubMed  Google Scholar 

  • Ryan, D. P., C. C. Compton, and R. J. Mayer. 2000. Carcinoma of the anal canal. N Engl J Med 342:792–800.

    Article  PubMed  CAS  Google Scholar 

  • Schiffman, M., and S. K. Kjaer. 2003. Chapter 2: Natural history of anogenital human papillomavirus infection and neoplasia. J Natl Cancer Inst Monogr:14–19.

    Google Scholar 

  • Abbas, A., G. Yang, and M. Fakih. 2010. Management of anal cancer in 2010. Part 1: Overview, screening, and diagnosis. Oncology (Williston Park) 24:364–369.

    Google Scholar 

  • Uronis, H. E., and J. C. Bendell. 2007. Anal cancer: an overview. Oncologist 12:524–534.

    Article  PubMed  Google Scholar 

  • National Cancer Institute.

    Google Scholar 

  • Greene, M. D. 2009. Diagnosis and management of HPV-related anal dysplasia. Nurse Pract 34:45–51.

    Article  PubMed  Google Scholar 

  • Huang, C. M. 2008. Human papillomavirus and vaccination. Mayo Clin Proc 83:701–706; quiz 706–707.

    Google Scholar 

  • Campo, M. S., and R. B. Roden. 2010. Papillomavirus prophylactic vaccines: established successes, new approaches. J Virol 84:1214–1220.

    Article  PubMed  CAS  Google Scholar 

  • Lin, K., E. Roosinovich, B. Ma, C. F. Hung, and T. C. Wu. 2010. Therapeutic HPV DNA vaccines. Immunol Res 47:86–112.

    Article  PubMed  CAS  Google Scholar 

  • Schiller, J. T., X. Castellsague, L. L. Villa, and A. Hildesheim. 2008. An update of prophylactic human papillomavirus L1 virus-like particle vaccine clinical trial results. Vaccine 26 Suppl 10:K53–61.

    Article  PubMed  CAS  Google Scholar 

  • Barroso, L. F., 2nd, and T. Wilkin. 2010. Human papillomavirus vaccination in males: the state of the science. Curr Infect Dis Rep 13:175–181.

    Article  Google Scholar 

  • Merck & Co., I. 2010. Human papillomavirus quadrivalent [types 6, 11, 16, and 18] vaccine, recombinant suspension for intramuscular injection) product information.

    Google Scholar 

  • Julius, J. M., L. Ramondeta, K. A. Tipton, L. S. Lal, K. Schneider, and J. A. Smith. 2010. Clinical perspectives on the role of the human papillomavirus vaccine in the prevention of cancer. Pharmacotherapy 31:280–297.

    Article  Google Scholar 

  • Garland, S. M., M. Hernandez-Avila, C. M. Wheeler, G. Perez, D. M. Harper, S. Leodolter, G. W. Tang, D. G. Ferris, M. Steben, J. Bryan, F. J. Taddeo, R. Railkar, M. T. Esser, H. L. Sings, M. Nelson, J. Boslego, C. Sattler, E. Barr, and L. A. Koutsky. 2007. Quadrivalent vaccine against human papillomavirus to prevent anogenital diseases. N Engl J Med 356:1928–1943.

    Article  PubMed  CAS  Google Scholar 

  • Centers for Disease Control and Prevention. 2010. FDA licensure of bivalent human papillomavirus vaccine (HPV2, Cervarix) for use in females and updated HPV vaccination recommendations from the Advisory Committee on Immunization Practices (ACIP). MMWR Morb Mortal Wkly Rep 59:626–629.

    Google Scholar 

  • GlaxoSmithKline. 2011. Cervarix (human papillomavirus bivalent [types 16 and 18] vaccine, recombinant suspension for intramuscular injection) product information.

    Google Scholar 

  • Gallagher, T. Q., and C. S. Derkay. 2008. Recurrent respiratory papillomatosis: update 2008. Curr Opin Otolaryngol Head Neck Surg 16:536–542.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. College of Dentistry, Department of Oral Medicine and Diagnostic Sciences, University of Illinois at Chicago, MC838, 801 South Paulina Street, Chicago, IL, 60612, USA

    Herve Y. Sroussi, Mahesh Patel, Sara C. Gordon & Robert J. Cabay

Authors
  1. Herve Y. Sroussi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mahesh Patel
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Sara C. Gordon
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Robert J. Cabay
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Herve Y. Sroussi .

Editor information

Editors and Affiliations

  1. S Paulina St 801, Chicago, 60612, USA

    James A. Radosevich

Rights and permissions

Reprints and permissions

Copyright information

© 2012 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

Sroussi, H.Y., Patel, M., Gordon, S.C., Cabay, R.J. (2012). Malignant Diseases Associated with Human Papillomavirus Infection. In: Radosevich, J. (eds) HPV and Cancer. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-5437-9_7

Download citation

Publish with us

Policies and ethics

Search

Navigation