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Benign Diseases Associated with Human Papillomavirus Infection

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Abstract

This chapter summarizes the clinical and diagnostic features, treatment, and prognosis of common Human Papillomavirus (HPV) infection. It discusses benign HPV-associated warts that occur exclusively on skin, on mucosa and adjacent skin, and in syndromes. These include: Butcher’s Wart, Cystic Wart (Plantar Epidermoid Inclusion Cyst), Filiform Wart, Verruca Plana (Flat Wart), Verruca Vulgaris (including Oral Verruca Vulgaris, Verruca Plantaris, Mosaic Wart, and Periungual Wart), Bowenoid Papulosis, Condyloma Acuminatum (Genital Wart), Conjunctival Papilloma, Focal Epithelial Hyperplasia (Heck’s Disease), Laryngeal Papillomatosis (Recurrent Respiratory Papillomatosis), Sinonasal Papilloma (Inverted, Fungiform, and Oncocytic types), and verricoses in congenital immunodeficiency diseases including Epidermodysplasia Verruciformis, Netherton Syndrome, WHIM Syndrome, WILD Syndrome, and Generalized Verrucosis.

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Abbreviations

HPV:

Human Papillomavirus

BP:

Bowenoid papulosis

PCR:

Polymerase Chain Reaction

RRP:

Recurrent Respiratory Papillomatosis

WHO:

World Health Organization

EBV:

Epstein-Barr Virus

CT:

Computed Tomography

MRI:

Magnetic Resonance Imaging

EV:

Epidermodysplasia Verruciformis

PUVA:

Psoralen and Ultraviolet A (phototherapy)

WHIM:

Warts/Hypogammaglobulinemia/ Infections/Myelokathexis

G-CSF:

Granulocyte Colony - Stimulating Factor

GV:

Generalizaed Verrucosis

AIDS:

Acquired Immunodeficiency Disease

References

  • de Villiers EM, Fauquet C, Broker TR, Bernard HU, zur Hausen H (2004) Classification of papillomaviruses. Virology 324:17–27

    Article  PubMed  Google Scholar 

  • Anderson KM, Perez-Montiel D, Miles L, Allen CM, Nuovo GJ (2003) The histologic differentiation of oral condyloma acuminatum from its mimics. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 96:420–428

    Article  PubMed  Google Scholar 

  • Gearhart PA, Randall TC, Buckley RM (2011) Human Papillomavirus.eMedicine from WebMD. [Epub] Accessed online 11 September 2011 at: http://emedicine.medscape.com

  • Syrjänen KJ (2003) HPV infections in benign and malignant sinonasal lesions. J Clin Pathol 56:174–181

    Article  PubMed  Google Scholar 

  • Trottier H, Burchell AN (2009) Epidemiology of Mucosal Human Papillomavirus Infection and Associated Diseases. Public Health Genomics 12:291–307

    Article  PubMed  Google Scholar 

  • Schenefelt PD (2010) Nongenital warts. eMedicine from WebMD. [Epub] Accessed online 11 September 2011 at: http://emedicine.medscape.com

  • Stulberg DL, Hutchinson AG Molluscum contagiosum and warts. (2003) Am Fam Physician. 67:1233–1240. [Epub] Accessed online 11 September 2011 online at: http://www.aafp.org

  • Keefe M, al-Ghamdi A, Coggon D et al. (1994a) Butchers’ warts: no evidence for person to person transmission of HPV7. Br J Dermatol 130:15–17

    Article  PubMed  CAS  Google Scholar 

  • Keefe M, al-Ghamdi A, Coggon D et al. (1994b) Cutaneous warts in butchers. Br J Dermatol 130:9–14

    Article  PubMed  CAS  Google Scholar 

  • Melchers W, de Mare S, Kuitert E, Galama J, Walboomers J, van den Brule AJ (1993) Human papillomavirus and cutaneous warts in meat handlers. J Clin Microbiol. 31:2547–2549. [Epub] Accessed online 11 September 2011 at: http://www.ncbi.nlm.nih.gov

    Google Scholar 

  • Rüdlinger R, Bunney MH, Grob R, Hunter JA (1989) Warts in fish handlers. Br J Dermatol 120:375–381

    Article  PubMed  Google Scholar 

  • Handisurya A, Schellenbacher C, Kirnbauer R Diseases caused by human papillomaviruses (HPV). (2009) J Dtsch Dermatol Ges 7:453–466

    PubMed  Google Scholar 

  • Jablońska S, Obalek S, Favre M, Golebiowska A, Croissant O, Orth G (1987) The morphology of butchers’ warts as related to papillomavirus types. Arch Dermatol Res 279 Suppl:S66–72

    Article  PubMed  Google Scholar 

  • Ritzkowsky A, Weissenborn S, Krieg T, Pfister H, Wieland U (2001) Extensive human papillomavirus type 7-associated orofacial warts in an immunocompetent patient. Acta Derm Venereol 81:130–133

    Article  PubMed  CAS  Google Scholar 

  • De Peuter M, De Clerc B, Minette A, Lachapelle JM (1977) An epidemiological survey of virus warts of the hands among butchers. Br J Dermatol 96:427–431

    Article  PubMed  Google Scholar 

  • Egawa K, Egawa N, Honda Y (2005) Human papillomavirus-associated plantar epidermoid cyst related to epidermoid metaplasia of the eccrine duct epithelium: a combined histological, immunohistochemical, DNA-DNA in situ hybridization and three-dimensional reconstruction analysis. Br J Dermatol 152:961–967

    Article  PubMed  CAS  Google Scholar 

  • Park HS, Kim WS, Lee JH, et al. (2005) Association of Human Papillomavirus Infection with Palmoplantar Epidermal Cysts in Korean Patients. Acta Derm Venereol 85:404–408. [Epub] Accessed online 11 September 2011 at: http://www.medicaljournals.se

  • Schenefeldt PD (2010) Nongenital Warts. eMedicine from WebMD [Epub] Accessed online 11 September 2011 at: http://emedicine.medscape.com

  • Coulter PD, Bouché RT (1999) Traumatically induced inclusion cyst secondary to shoe impingement: report of three cases. J Foot Ankle Surg. 38:271–277

    Article  PubMed  CAS  Google Scholar 

  • Hall JP, Sheffey RJ, Chagares WE, Yong RM (2006) Epidermal inclusion cyst in the foot of a Vietnam Veteran. J Am Podiatr Med Assoc 96:445–447

    PubMed  Google Scholar 

  • Corley E, Pueyo S, Goc B, Diaz A, Zorzopulos J. (1988) Papillomaviruses in human skin warts and their incidence in an Argentine population. Diagn Microbiol Infect Dis 10:93–101

    Article  PubMed  CAS  Google Scholar 

  • Goodheart HP (2003) Surgical Pearl: A rapid technique for destroying small skin tags and filiform warts. Dermatol Online J 9:34. [Epub] Accessed online 11 September 2011 at: http://dermatology.cdlib.org

  • Al-Bakkal G, Ficarra G, McNeill K, Eversole LR, Sterrantino G, Birek C (1999) Human papilloma virus type 16 E6 gene expression in oral exophytic epithelial lesions as detected by in situ rtPCR. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 87:197–208

    Article  PubMed  CAS  Google Scholar 

  • Gordon SC, Ganatra S, Foong WC, Sroussi HY (2009) Viral Infections of the Mouth. eMedicine from WebMD [Epub] Accessed online 11 September 2011 at: http://emedicine.medscape.com

  • Lipke MM (2006) An armamentarium of wart treatments. Clin Med Res 4:273–293. [Epub] Accessed online 11 September 2011 at: http://www.ncbi.nlm.nih.gov

    Google Scholar 

  • Gibbs S, Harvey I (2006) Topical treatments for cutaneous warts. Cochrane Database of Systematic Reviews 3. [Epub] Art. No.: CD001781. DOI: 10.1002/14651858.CD001781.pub2. Accessed online 11 September 2011 at: http://www2.cochrane.org

  • DiPreta EA, Maggio K (2010) Bowenoid Papulosis. eMedicine from WebMD. [Epub] Accessed online 11 September 2011 at: http://emedicine.medscape.com

  • Ghadishah D (2009) Condyloma acuminatum. eMedicine from WebMD. [Epub] Accessed online 11 September 2011 at: http://emedicine.medscape.com

  • Daley T, Birek C, Wysocki GP (2000) Oral bowenoid lesions: Differential diagnosis and pathogenetic insights. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 90:466–473

    Article  PubMed  CAS  Google Scholar 

  • Rinaggio J, Glick M, Lambert WC (2006a) Oral bowenoid papulosis in an HIV-positive male. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 101:328–332

    Article  PubMed  Google Scholar 

  • Cox D, Greenspan D, Jordan RCK, Greenspan JS (2006) Letter to the editor. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 102: 431–432

    Article  PubMed  Google Scholar 

  • Henquet C (2011) Anogenital malignancies and pre-malignancies. J Eur Acad Dermatol Venereol. [Epub ahead of print]. Accessed online 11 September 2011 at: http://onlinelibrary.wiley.com

  • Rinaggio J, Glick M, Lambert WC (2006b) Response to letter to the editor by Cox et al. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 102:432

    Google Scholar 

  • Flaitz C, Nichols M, Vigneswaran N, Bouquot J, Zuluaga A (2011) Oral warts in HIV-infected individuals exhibit lack of tissue autofluorescence: a clinicopathologic study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 111:e51. [Epub] Accessed online 11 September 2011 at: http://www.sciencedirect.com.proxy.cc.uic.edu/science/article/pii/S107921041773

  • Wenig BM (2008) Human Papillomavirus (HPV)-related diseases. In: Atlas of Head and Neck Pathology 2nd ed. Philadelphia, Pa: WB Saunders 204–205

    Google Scholar 

  • Sjö NC, Heegaard S, Prause JU, von Buchwald C, Lindeberg H (2001) Human papillomavirus in conjunctival papilloma. Br J Ophthalmol. 85:785–787

    Article  PubMed  Google Scholar 

  • Duong, HQ and Copeland, R (2001) Papilloma, Conjunctival: eMedicine Ophthalmology from WebMD. [Epub] Accessed 11 September 2011 at: http://emedicine.medscape.com

  • Sjö NC, von Buchwald C, Cassonnet P et al. (2007) Human papillomavirus in normal conjunctival tissue and in conjunctival papilloma: types and frequencies in a large series. Br J Ophthalmol 91:1014–1015

    Article  PubMed  Google Scholar 

  • Buggage RR, Smith JA, Shen D, Chan CC (2002) Conjunctival papillomas caused by human papillomavirus type 33. Arch Ophthalmol 120:202–204

    Article  PubMed  Google Scholar 

  • Shields CL, Shields JA (2004) Tumors of the conjunctiva and cornea. Surv Ophthalmol 49:3–24

    Article  PubMed  Google Scholar 

  • Sen S, Sharma A, Panda A (2007) Immunohistochemical localization of human papilloma virus in conjunctival neoplasias: a retrospective study. Indian J Ophthalmol 55:361–363

    Article  PubMed  Google Scholar 

  • Hall C, McCullogh M, Angel C, Manton D (2010) Multifocal epithelial hyperplasia: a case report of a family of Somalian descent living in Australia. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 109:e20–e24. [Epub] Accessed online 11 September 2011 at: http://www.sciencedirect.com.proxy.cc.uic.edu/science/article/pii/S107921040900674X

    Google Scholar 

  • Feller L, Khammissa RA, Wood NH, Malema V, Meyerov R, Lemmer J (2010) Focal epithelial hyperplasia (Heck disease) related to highly active antiretroviral therapy in an HIV-seropositive child. A report of a case, and a review of the literature. SADJ 65:172–175

    PubMed  CAS  Google Scholar 

  • Durso BC, Pinto JM, Jorge J Jr, de Almeida OP (2005) Extensive focal epithelial hyperplasia: case report. J Can Dent Assoc 71:769–771

    PubMed  Google Scholar 

  • Larson DA, Derkay CS (2010) Epidemiology of recurrent respiratory papillomatosis. APMIS 118:450–454

    Article  PubMed  Google Scholar 

  • Silverberg MJ, Thorsen P, Lindeberg H, Grant LA, Shah KV (2003) Condyloma in pregnancy is strongly predictive of juvenile-onset recurrent respiratory papillomatosis. Obstet Gynecol 101:645–652

    Article  PubMed  Google Scholar 

  • Donne AJ, Clarke R (2010) Recurrent respiratory papillomatosis: an uncommon but potentially devastating effect of human papillomavirus in children. Int J STD AIDS 21:381–385

    Article  PubMed  CAS  Google Scholar 

  • Xue Q, Wang H, Wang J (2010) Recurrent respiratory papillomatosis: an overview. Eur J Clin Microbiol Infect Dis 29:1051–1054.

    Article  PubMed  Google Scholar 

  • Andrus JG, Shapshay SM (2006) Contemporary management of laryngeal papilloma in adults and children. Otolaryngol Clin North Am 39:135–158

    Article  PubMed  Google Scholar 

  • Wiatrak BJ (2003) Overview of recurrent respiratory papillomatosis. Curr Opin Otolaryngol Head Neck Surg 11:433–441

    Article  PubMed  Google Scholar 

  • Derkay CS, Wiatrak B (2008) Recurrent respiratory papillomatosis: a review. Laryngoscope 118:1236–1247

    Article  PubMed  Google Scholar 

  • Hester RP, Derkay CS, Burke BL, Lawson ML (2003) Reliability of a staging assessment system for recurrent respiratory papillomatosis. Int J Pediatr Otorhinolaryngol 67:505–509

    Article  PubMed  Google Scholar 

  • Derkay CS (2001) Recurrent respiratory papillomatosis. Laryngoscope 111:57–69

    Article  PubMed  CAS  Google Scholar 

  • El-Bitar MA, Zalzal GH (2002) Powered instrumentation in the treatment of recurrent respiratory papillomatosis: an alternative to the carbon dioxide laser. Arch Otolaryngol Head Neck Surg 128:425–428

    PubMed  Google Scholar 

  • Chadha NK, James A (2010) Adjuvant antiviral therapy for recurrent respiratory papillomatosis. Cochrane Database Syst Rev 20:CD005053

    Google Scholar 

  • Barnes L (2002) Schneiderian papillomas and nonsalivary glandular neoplasms of the head and neck. Mod Pathol 15:279–297

    Article  PubMed  Google Scholar 

  • Eggers G, Mühling J, Hassfeld S (2007) Inverted papilloma of paranasal sinuses. J Craniomaxillofac Surg 35:21–29

    Article  PubMed  Google Scholar 

  • Anari S, Carrie S (2010) Sinonasal inverted papilloma: narrative review. J Laryngol Otol 124:705–715

    Article  PubMed  CAS  Google Scholar 

  • Sadeghi N, Al-Dhahri S, Manoukian JJ (2003) Transnasal endoscopic medial maxillectomy for inverting papilloma. Laryngoscope 113:749–753

    Article  PubMed  Google Scholar 

  • Batra PS, Citardi MJ (2006) Endoscopic management of sinonasal malignancy. Otolaryngol Clin North Am 39:619–37, x–xi

    Google Scholar 

  • Sauter A, Matharu R, Hörmann K, Naim R (2007) Current advances in the basic research and clinical management of sinonasal inverted papilloma (review). Oncol Rep 17:495–504

    PubMed  CAS  Google Scholar 

  • Mirza S, Bradley PJ, Acharya A, Stacey M, Jones NS (2007) Sinonasal inverted papillomas: recurrence, and synchronous and metachronous malignancy. J Laryngol Otol 121:857–864

    Article  PubMed  CAS  Google Scholar 

  • Rogers HD, Macgregor JL, Nord KM et al. (2009) Acquired epidermodysplasia verruciformis. J Am Acad Dermatol 60:315–320

    Article  PubMed  Google Scholar 

  • Gewirtzman A, Bartlett B, Tyring S (2008) Epidermodysplasia verruciformis and human papilloma virus. Curr Opin Infect Dis 21:141–146

    Article  PubMed  Google Scholar 

  • Lane JE, Bowman PH, Cohen DJ (2003) Epidermodysplasia verruciformis. South Med J 96:613–615

    Article  PubMed  Google Scholar 

  • Majewski S, Jablonska S (1997) Human papillomavirus-associated tumors of the skin and mucosa. J Am Acad Dermatol 36:659–685

    Article  PubMed  CAS  Google Scholar 

  • Sun JD, Linden KG (2006) Netherton syndrome: a case report and review of the literature. Int J Dermatol 45:693–697

    Article  PubMed  Google Scholar 

  • Fölster-Holst R, Swensson O, Stockfleth E, Mönig H, Mrowietz U, Christophers E (1999) Comèl-Netherton syndrome complicated by papillomatous skin lesions containing human papillomaviruses 51 and 52 and plane warts containing human papillomavirus 16. Br J Dermatol 140:1139–1143

    Article  PubMed  Google Scholar 

  • Weber F, Fuchs PG, Pfister HJ, Hintner H, Fritsch P, Hoepfl R (2001) Human papillomavirus infection in Netherton’s syndrome. Br J Dermatol 144:1044–1049

    Article  PubMed  CAS  Google Scholar 

  • Krasagakis K, Ioannidou DJ, Stephanidou M, Manios A, Panayiotides JG, Tosca AD (2003) Early development of multiple epithelial neoplasms in Netherton syndrome. Dermatology 207:182–184

    Article  PubMed  CAS  Google Scholar 

  • Cipriani NA, Blair E, Taxy JB (2010) WHIM syndrome and oral squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 109:105–108

    Article  PubMed  Google Scholar 

  • Kawai T, Malech HL (2009) WHIM Syndrome: Congenital Immune Deficiency Disease. Curr Opin Hematol 16:20–26

    Article  PubMed  CAS  Google Scholar 

  • Hernandez PA, Gorlin RJ, Lukens JN, Taniuchi S, Bohinjec J, Francois F, Klotman ME, Diaz GA (2003) Mutations in the chemokine receptor gene CXCR4 are associated with WHIM syndrome, a combined immunodeficiency disease. Nat Genet 34:70–74

    Article  PubMed  CAS  Google Scholar 

  • Kreuter A, Hochdorfer B, Brockmeyer NH et al. (2008) A human papillomavirus-associated disease with disseminated warts, depressed cell-mediated immunity, primary lymphedema, and anogenital dysplasia: WILD syndrome. Arch Dermatol 144:366–372

    Article  PubMed  Google Scholar 

  • Ostrow RS, Manias D, Mitchell AJ, Stawowy L, Faras AJ (1987) Epidermodysplasia verruciformis. A case associated with primary lymphatic dysplasia, depressed cell-mediated immunity, and Bowen’s disease containing human papillomavirus 16 DNA. Arch Dermatol 123:1511–1516

    Article  PubMed  CAS  Google Scholar 

  • Kreuter A, Waterboer T, Wieland U (2010) Regression of cutaneous warts in a patient with WILD syndrome following recombinant quadrivalent human papillomavirus vaccination. Arch Dermatol 146:1196–1197

    Article  PubMed  Google Scholar 

  • Alisjahbana B, Dinata R, Sutedja E et al. (2010) Disfiguring generalized verrucosis in an indonesian man with idiopathic CD4 lymphopenia. Arch Dermatol 146:69–73

    Article  PubMed  Google Scholar 

  • Yanagi T, Shibaki A, Tsuji-Abe Y, Yokota K, Shimizu H (2006) Epidermodysplasia verruciformis and generalized verrucosis: the same disease? Clin Exp Dermatol 31:390–393

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. College of Dentistry, Department of Oral Medicine and Diagnostic Sciences, University of Illinois at Chicago, MC838, 801 South Paulina Street, Chicago, IL, 60612, USA

    Sara C. Gordon, Mahesh C. Patel, Robert J. Cabay & Hervé Y. Sroussi

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  1. Sara C. Gordon
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  2. Mahesh C. Patel
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  3. Robert J. Cabay
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  4. Hervé Y. Sroussi
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Correspondence to Sara C. Gordon .

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  1. S Paulina St 801, Chicago, 60612, USA

    James A. Radosevich

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Gordon, S.C., Patel, M.C., Cabay, R.J., Sroussi, H.Y. (2012). Benign Diseases Associated with Human Papillomavirus Infection. In: Radosevich, J. (eds) HPV and Cancer. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-5437-9_6

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