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The Life Cycle of Human Papillomavirus

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HPV and Cancer

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Abstract

This chapter provides an overview of the life cycle of the human papillomavirus (HPV), including: (1) infection, (2) genome maintenance and cell proliferation, (3) genome amplification, (4) virus assembly and release, and (5) integration and tumor progression. While many of the processes involved with the HPV life cycle are still not well known, this chapter summarizes the research to date that has formed our current understanding of the cellular mechanisms driving each of these steps. Furthermore, this chapter describes known differences in the life cycle of high-risk and low-risk HPV infections, and the resulting tumor progression associated with each.

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Abbreviations

HPV:

Human Papillomavirus

TA:

Transit Amplifying cells

GAG:

Glycoaminoglycan

HSPs:

Heparan Sulfate Proteoglycans

HS:

Heparon Sulfate

VLPs:

Virus Like Particles

CyPB:

Cyclophilin B

ECM:

Extracellular Matrix

LN 5:

Laminin 5

ER:

Endoplasmic Reticulum

ND 10:

Nuclear Domain 10

PML:

Promyelocytic Leukemia protein

PODs:

PML Oncogenic Domains

DYNLT 1:

Dynein Light Chain

Brd 4:

Bromodomain-containing protein

Chl R1:

Chromosome Loss-related protein

NLSs:

Nuclear Localization Signals

nNLS:

N-terminus NLS

cNLS:

C-terminus NLS

LCR:

Long Control Region

DSBs:

Double Strands Breaks

CFSs:

Common Fragile Sites

C/EBP:

CLAAT/Enhancer Binding Protein

YY1:

Yin-Yang 1

CDP/Cut:

CCAAT displacement protein

AP1:

Activator Protein 1

L-SIL:

Low grade Squamous Intraepithelial Lesion

H-SIL:

High Grade Squamous Intraepithelial Lesion

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Authors and Affiliations

  1. College of Dentistry, Department of Oral and Diagnostic Medicine, University of Illinois at Chicago, 801 South Paulina, Chicago, IL, 60625, USA

    Jiaping Xue, Benjamin J. Vesper & James A. Radosevich

Authors
  1. Jiaping Xue
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  2. Benjamin J. Vesper
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  3. James A. Radosevich
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Correspondence to James A. Radosevich .

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Editors and Affiliations

  1. S Paulina St 801, Chicago, 60612, USA

    James A. Radosevich

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© 2012 Springer Science+Business Media Dordrecht

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Xue, J., Vesper, B.J., Radosevich, J.A. (2012). The Life Cycle of Human Papillomavirus. In: Radosevich, J. (eds) HPV and Cancer. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-5437-9_3

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