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Radiation Therapy of CNS Metastases

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Central Nervous System Metastasis, the Biological Basis and Clinical Considerations

Part of the book series: Cancer Metastasis - Biology and Treatment ((CMBT,volume 18))

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Abstract

Radiation treatment of central nervous system (CNS) metastases, particularly brain metastasis, is changing. The role of radiation for intraaxial disease was originally limited to palliation. However, now there is an increasing expectation by both patients and physicians to integrate radiotherapy in an overall strategy for eradication of disease. Recent innovations in radiobiology and technical advances in radiotherapy have proven beneficial to many extracranial sites. Nevertheless, these advances have lagged behind in the treatment of brain and spinal metastases and have not kept pace with changing expectations. We aim to explain the scientific basis of radiotherapy for CNS metastasis, current treatment options and techniques, controversies, and future goals for potential improvement.

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  1. Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, 20892, MD, USA

    DeeDee Smart M.D., Ph.D.

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Correspondence to DeeDee Smart M.D., Ph.D. .

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  1. , Laboratory of Molecular Pharmacology, National Cancer Institute, Convent Drive Building 3, Bethesda, 20892, Maryland, USA

    Diane Palmieri

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Smart, D. (2012). Radiation Therapy of CNS Metastases. In: Palmieri, D. (eds) Central Nervous System Metastasis, the Biological Basis and Clinical Considerations. Cancer Metastasis - Biology and Treatment, vol 18. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-5291-7_9

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