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Biobanking in Pediatric Research

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Pediatric Biomedical Informatics

Part of the book series: Translational Bioinformatics ((TRBIO,volume 2))

Abstract

Modern pediatric disease research requires rapid access to high quality biospecimens. Morphological studies require precise sample preservation while genetic studies often require thousands of samples to identify biologically or clinically relevant findings. To have the necessary number of samples requires specialized centers called biobanks to collect, process, store and distribute biospecimens and associated clinical data. Records of the biospecimen lifecycle must be maintained to ensure that samples are fit-for-purpose and to avoid spurious results that can cost time and money as well as possibly harming patients. Informatics solutions to sample management can vary from basic sample tracking systems to full laboratory information management systems (LIMS). These tracking systems can be ‘organic’ in-house software systems or commercial software packages. While attention to sample collection is imperative for biobanked samples, sample utility is generally proportional to the quality and quantity of associated clinical data. One benefit of centralized biobanking operations is economies of scale allowing development of interfaces between clinical data from a local electronic medical record (EMR) or research patient data warehouse and de-identified biobank samples. This combination allows previously un-contemplated research projects. Regulatory compliance in pediatric biospecimen collections requires consideration of many issues around informed consent, assent, and reconsent at the age of majority. Finally, issues surrounding return of incidental findings are becoming prevalent in the post-genomics era. The components and benefits of various sample management strategies will be discussed with a focus on ensuring sample quality and integration with clinical data.

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Acknowledgements

This publication was supported in part by an Institutional Clinical and Translational Science Award, NIH/NCATS Grant Number 8UL1TR07-04. Its contents are solely the responsibility of the author and do not necessarily represent the official views of the NIH.

Author information

Authors and Affiliations

  1. Division of Rheumatology, Cincinnati BioBank Core Facility, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Ave ML 4010, Cincinnati, OH, 45229-3039, USA

    Michael G. Barnes Ph.D.

  2. Department of Communication, McMicken College of Arts & Sciences, University of Cincinnati, Cincinnati, OH, USA

    John A. Lynch Ph.D.

  3. Center for Clinical and Translational Science and Training, University of Cincinnati College of Medicine, Cincinnati, OH, USA

    John A. Lynch Ph.D.

  4. Research Compliance and Regulatory Affairs, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Ave, ML 4010, Cincinnati, OH, 45229-3039, USA

    Jeremy J. Corsmo MPH, CIP, CHRC

  5. Departments of Pathology and Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA

    David P. Witte M.D.

  6. Division of Pathology and Laboratory Medicine, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Ave, ML 4010, Cincinnati, OH, 45229-3039, USA

    David P. Witte M.D.

  7. Departments of Pathology and Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH, USA

    Paul E. Steele M.D.

  8. Clinical Laboratory, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Ave, ML 4010, Cincinnati, OH, 45229-3039, USA

    Paul E. Steele M.D.

Authors
  1. Michael G. Barnes Ph.D.
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  2. John A. Lynch Ph.D.
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  3. Jeremy J. Corsmo MPH, CIP, CHRC
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  4. David P. Witte M.D.
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  5. Paul E. Steele M.D.
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Corresponding author

Correspondence to Michael G. Barnes Ph.D. .

Editor information

Editors and Affiliations

  1. Burnet Ave 3333, Cincinnati, 45229-3026, Ohio, USA

    John J. Hutton

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© 2012 Springer Science+Business Media Dordrecht

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Barnes, M.G., Lynch, J.A., Corsmo, J.J., Witte, D.P., Steele, P.E. (2012). Biobanking in Pediatric Research. In: Hutton, J. (eds) Pediatric Biomedical Informatics. Translational Bioinformatics, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-5149-1_7

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