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Pediatric Biomedical Informatics pp 173–192Cite as

Natural Language Processing: Applications in Pediatric Research

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Part of the book series: Translational Bioinformatics ((TRBIO,volume 2))

Abstract

We discuss specific biomedical Natural Language Processing-based applications that cover a wide spectrum of use cases within the field of translational and health services research. In our use cases we focus on four categories of applications: (1) Information Extraction (IE), (2) Document Classification, (3) Patient Classification, and (4) Sentiment Analysis. We show how the extracted information could be used for (a) Phenotype identification, (b) Comparative effectiveness studies, (c) Cohort identification, (d) Meaningful Use, and (e) Linking patients’ phenotype and genotype. In addition, we discuss the use of Natural Language Processing components for de-identification of large collections of patient notes. We review the literature for examples of pediatric natural language processing applications and show the transferability of select adult clinical natural language processing applications to the pediatric population.

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Acknowledgements

Dr. Savova’s work was supported in part by NIH grants U54LM008748 and 1U01HG006828. Drs. Deleger’s and Solti’s work was supported in part by NIH grant 5R00LM010227.

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Authors and Affiliations

  1. Boston Children’s Hospital, Harvard Medical School, Harvard University, 300 Longwood Avenue, Enders 138, Boston, MA, 02115, USA

    Guergana K. Savova Ph.D.

  2. Divisions of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, ML-7024, Cincinnati, OH, 45229-3039, USA

    Louise Deleger Ph.D., Imre Solti M.D., Ph.D., M.A. & John Pestian Ph.D.

  3. Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA

    Imre Solti M.D., Ph.D., M.A., John Pestian Ph.D. & Judith W. Dexheimer Ph.D.

  4. Divisions of Emergency Medicine and Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, ML-7024, Cincinnati, OH, 45229-3039, USA

    Judith W. Dexheimer Ph.D.

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  1. Guergana K. Savova Ph.D.
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  2. Louise Deleger Ph.D.
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  3. Imre Solti M.D., Ph.D., M.A.
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  4. John Pestian Ph.D.
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  5. Judith W. Dexheimer Ph.D.
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Correspondence to Guergana K. Savova Ph.D. .

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  1. Burnet Ave 3333, Cincinnati, 45229-3026, Ohio, USA

    John J. Hutton

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Savova, G.K., Deleger, L., Solti, I., Pestian, J., Dexheimer, J.W. (2012). Natural Language Processing: Applications in Pediatric Research. In: Hutton, J. (eds) Pediatric Biomedical Informatics. Translational Bioinformatics, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-5149-1_10

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