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The Role of Nitric Oxide in the Regulation of Ion Channels in the Cardiomyocytes: Link to Mechanically Gated Channels

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Book cover Mechanically Gated Channels and their Regulation

Part of the book series: Mechanosensitivity in Cells and Tissues ((MECT,volume 6))

Abstract

This review is devoted to the role of nitric oxide in the regulation of ion channels in the cardiomyocytes. Here we consider issues of regulation of mechanically gated channels by means of NO. Firstly we address the modulatory effect of nitric oxide on voltage gated Na+-, Ca2+-, K+-channels, which contribute them most to formation of action potential and its shape under normal as well as under pathological conditions in heart. We address separately effect of nitric oxide on leak channels (two-pore potassium channels), some of which are mechanosensitive. Finally we discuss the effect of nitric oxide on mechanically gated ion channels and mechanically gated currents. In our manuscript we show that without consideration of NO effects on voltage gated channels, investigation of nitric oxide effect on mechanically gated channels in heart under normal of pathological conditions would be incomplete.

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Acknowledgements

This work was supported by the Russian Foundation for Basic Research (grant no. 09-04-01277-a). Department of Fundamental and Applied Physiology (Professor and Chairman—Andre Kamkin) was supported by Ministry of Education and Science of the Russian Federation. The Order of Ministry of Education and Science of the Russian Federation No. 743 from 01 July 2010, Supplement, Event 4.4, the Period of Financing 2010–2019.

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  1. Department of Fundamental and Applied Physiology, Laboratory of Electrophysiology, Russian State Medical University, Ostrovitjanova 1, 117997, Moscow, Russia

    Ekaterina Yu. Makarenko, Ilya Lozinsky & Andre Kamkin

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  1. Ekaterina Yu. Makarenko
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  2. Ilya Lozinsky
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  3. Andre Kamkin
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Correspondence to Andre Kamkin .

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  1. Chemical Department, Moscow State University, Vorobiovy Gory MSU, Moscow, 119899, Russia

    Andre Kamkin

  2. , Fundamental and Applied Physiology, Russian State Medical University, Ostrovitjanova Str 1, Moscow, 117997, Russia

    Ilya Lozinsky

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Makarenko, E.Y., Lozinsky, I., Kamkin, A. (2012). The Role of Nitric Oxide in the Regulation of Ion Channels in the Cardiomyocytes: Link to Mechanically Gated Channels. In: Kamkin, A., Lozinsky, I. (eds) Mechanically Gated Channels and their Regulation. Mechanosensitivity in Cells and Tissues, vol 6. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-5073-9_8

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