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Mechanically Gated Channels and their Regulation pp 69–102Cite as

TRPV1 in Cell Signaling: Molecular Mechanisms of Function and Modulation

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Part of the book series: Mechanosensitivity in Cells and Tissues ((MECT,volume 6))

Abstract

The TRPV1 channel is a polymodal receptor that has been implicated in several physiological and pathological processes including painful stimuli detection, inflammation, hyperalgesia and, recently, mechanotransduction. This channel can be directly activated by acidic pH, bioactive lipids, cysteine-modifying molecules, extracellular cations, voltage, elevated temperatures and several exogenous molecules such as capsaicin and toxins from animals. Moreover, its function can be modulated by the action of protein kinases, lipids, the cytoskeleton, second messengers and many proteins involved in signaling processes. Hence, the TRPV1 channel sits in the middle of the cell’s intracellular signaling network and its communication with the external environment. Understanding the molecular mechanisms that govern TRPV1 channel function will certainly allow us to obtain a deeper insight into the physiology of cells and organisms. Here we review the latest discoveries pertaining the mechanisms and signaling processes that affect TRPV1 activity.

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Acknowledgements

This work was supported by grants from PAPIIT IN204111, CONACyT CB-129474 and a Grant from Fundación Miguel Alemán to T.R.

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Authors and Affiliations

  1. Departamento de Neurodesarrollo y Fisiología, División Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, México, D.F., México

    Tamara Rosenbaum

  2. Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, México, D.F., México

    Andrés Jara-Oseguera

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  1. Tamara Rosenbaum
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  2. Andrés Jara-Oseguera
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Correspondence to Tamara Rosenbaum .

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Editors and Affiliations

  1. Chemical Department, Moscow State University, Vorobiovy Gory MSU, Moscow, 119899, Russia

    Andre Kamkin

  2. , Fundamental and Applied Physiology, Russian State Medical University, Ostrovitjanova Str 1, Moscow, 117997, Russia

    Ilya Lozinsky

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Rosenbaum, T., Jara-Oseguera, A. (2012). TRPV1 in Cell Signaling: Molecular Mechanisms of Function and Modulation. In: Kamkin, A., Lozinsky, I. (eds) Mechanically Gated Channels and their Regulation. Mechanosensitivity in Cells and Tissues, vol 6. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-5073-9_3

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