Abstract
The transient receptor potential (TRP) proteins form a large Ca2+-permeable nonselective cation channel superfamily activated by physicochemical stimuli, and participate in a wide array of biological functions including sensory signal transduction. Recent investigations have disclosed that many of TRP channels expressed in the cardiovascular system (CVS) are activated by mechanical stresses operating therein such as membrane stretch, hypoosmolarity and shear stress. Although mechanisms proposed for mechanical signal transduction are diverse, accumulating evidence suggests that lipid mediators derived from phospholipase C (PLC)- and phospholipase A2 (PLA2)-dependent pathways may play central roles in the activation and regulation of these TRP channels. In this review, we focus on the lipid-mediated regulation of two TRP channels abundantly expressed in the CVS, i.e. TRPC6 and TRPV4, with particular interest in the synergistic interaction between receptor-mediated and mechanical stimulations, and discuss about their complex functional antagonism in vascular tone and blood pressure regulation.
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Acknowledgements
Part of this work is supported by Grants-in-aid for Scientific Research on Innovative Areas (No.22136008) and Scientific Research (C) (No. 21590246), and a grant from Seizon Kagaku Institute to R.I. Support was also obtained as a member from an oversea funding granted to Dr. Juan Shi at the Department of Anatomy and K.K. Leung Brian Research Center, the Fourth Military Medical University Xi′an (National Natural Science Foundation of China: No. 30871004).
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Inoue, R., Hu, Y., Duan, Y., Itsuki, K. (2012). Lipid-Mediated Mechanisms Involved in the Mechanical Activation of TRPC6 and TRPV4 Channels in the Vascular Tone Regulation. In: Kamkin, A., Lozinsky, I. (eds) Mechanically Gated Channels and their Regulation. Mechanosensitivity in Cells and Tissues, vol 6. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-5073-9_10
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