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Follicular Lymphoma: Recent Advances

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Hematologic Cancers: From Molecular Pathobiology to Targeted Therapeutics

Part of the book series: Cancer Growth and Progression ((CAGP,volume 14))

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Abstract

Follicular lymphoma (FL) is a B-cell lymphoma that recapitulates the germinal center (GC)-B-cell stage of differentiation and in most cases form neoplastic follicles that resemble the normal GC. Normal GCB-cells do not express the anti-apoptotic protein B-cell leukemia/lymphoma 2 (BCL2) and they readily undergo apoptosis if they do not have a high affinity antigen receptor that will transmit survival signals on recognition of the antigen. The vast majority of FL has a translocation that leads to an inappropriate constitutive expression of the BCL2 protein that protects the cell from apoptosis. This cell can survive for long periods in the GC environment and undergoes further genetic alterations that eventually establish the neoplastic clonal population as a FL. These critical secondary changes are of great interest in understanding the evolution of a pre-neoplastic clone with BCL2 translocation to a malignant lymphoma.

Alyssa Bouska and SharathKumar Bagvati contributed equally.

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Authors and Affiliations

  1. Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA

    Alyssa Bouska, SharathKumar Bagvati, Javeed Iqbal & Wing C. Chan M.D

  2. Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA

    Basem M. William

  3. Department of Pathology and Microbiology, Center for Research in Lymphoma and Leukemia, University of Nebraska Medical Center, 983135 Nebraska Medical Center, Omaha, NE, 68198-3135, USA

    Wing C. Chan M.D

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  1. Alyssa Bouska
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  2. SharathKumar Bagvati
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Correspondence to Wing C. Chan M.D .

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  1. Research Institute, Department of Hematopathology and, H. Lee Moffitt Cancer Center &, Magnolia Drive - MCC-LAB 12902, Tampa, 33612, Florida, USA

    Jianguo Tao

  2. Research Institute, Department of Malignant Hematology, H. Lee Moffitt Cancer Center &, Magnolia Drive 12902, Tampa, 33612, Florida, USA

    Eduardo Sotomayor

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Bouska, A., Bagvati, S., Iqbal, J., William, B.M., Chan, W.C. (2012). Follicular Lymphoma: Recent Advances. In: Tao, J., Sotomayor, E. (eds) Hematologic Cancers: From Molecular Pathobiology to Targeted Therapeutics. Cancer Growth and Progression, vol 14. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-5028-9_2

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