Abstract
Evaluation of the impact of traditional medicine on cancer cells has been challenging, for many reasons including challenges to obtain suitable cell models and reliable and predictive methods. This brief chapter explores the use electric cell-substrate sensing (ECIS) in evaluation of the effect of traditional Chinese medicine Yanzheng Xiaoji, commonly used in patients with cancer in China including gastrointestinal malignancies, on the cellular functions of gastric and colonic cancer cells. This study has shown that the extract from the formula had a substantial inhibitory effect on the adhesion and migration of gastric cancer cells (HGC27) and colorectal cancer cells (RKO). These effects were achieved at concentrations without affecting cell growth. It is concluded therefore that ECIS is a useful tool in evaluation of the effect of traditional medicine on cancer cells.
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The authors wish to thank Cancer Research Wales and Albert Hung Foundation for supporting their work.
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© 2012 Springer Science+Business Media Dordrecht
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Ye, L., Ji, K., Ji, J., Hargest, R., Jiang, W.G. (2012). Application of Electric Cell-Substrate Impedance Sensing in Evaluation of Traditional Medicine on the Cellular Functions of Gastric and Colorectal Cancer Cells. In: Jiang, W. (eds) Electric Cell-Substrate Impedance Sensing and Cancer Metastasis. Cancer Metastasis - Biology and Treatment, vol 17. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4927-6_10
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DOI: https://doi.org/10.1007/978-94-007-4927-6_10
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