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Anthocyanins as Apoptotic Regulators

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Novel Apoptotic Regulators in Carcinogenesis

Abstract

Bioactive compounds have been used traditionally in different cultures to promote human health. Anthocyanins (ACNs) are one of the most abundant dietary bioactive compounds and are responsible for the bright red, blue and purple colors of fruits and vegetables. There are over 600 different types of ACNs in nature, featuring six common aglycone structures, with different side chains attached. Although ACN bioavailability is low, ACNs and their gut metabolites possess biological activities that positively impact a variety of chronic diseases including cancer. This book chapter provides a brief summary of the synthesis and the bioavailability of ACNs and discusses the molecular mechanisms involved in ACN-induced apoptosis in cell culture, animal models and human clinical studies. Furthermore, ACN metabolism in vivo is also discussed, as the evidence indicates that the ACN meta­bolites are important pro-apoptotic agents. We hope that the presented evidence will help influence future research in the direction of furthering the scientific understanding of ACN pro-apoptotic properties in cancer.

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Authors and Affiliations

  1. Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, USA

    Jairam Vanamala, Sridhar Radhakrishnan & Aaron Massey

  2. Cancer Chemoprevention Section, University of Colorado Cancer Center, Aurora, CO, USA

    Jairam Vanamala

  3. Department of Horticulture and Landscape Architecture, Colorado State University, Fort Collins, CO, USA

    Lavanya Reddivari

Authors
  1. Jairam Vanamala
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  2. Sridhar Radhakrishnan
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  3. Lavanya Reddivari
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  4. Aaron Massey
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Corresponding author

Correspondence to Jairam Vanamala .

Editor information

Editors and Affiliations

  1. , Surgery, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, Hong Kong SAR

    George G. Chen

  2. , Surgery, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR

    Paul B.S. Lai

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© 2012 Springer Science+Business Media Dordrecht

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Vanamala, J., Radhakrishnan, S., Reddivari, L., Massey, A. (2012). Anthocyanins as Apoptotic Regulators. In: Chen, G., Lai, P. (eds) Novel Apoptotic Regulators in Carcinogenesis. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4917-7_4

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