Francisellaceae Representatives

  • Brian Austin
  • Dawn A. Austin


Francisella asiatica and Fr. noatunensis are intracellular pathogens which cause granulomatous disease. Isolation has been achieved initially in cell culture with subsequent growth on cysteine heart agar. Disease control has been achieved by vaccination and by use of antimicrobial compounds, notably florfenicol.


Blue Mussel Small Subunit rRNA Oxolinic Acid Farm Tilapia Noatunensis Subsp 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. Chern, R.S. and Chao, C.B. (1994) Outbreaks of disease caused by rickettsia-like organism in cultured tilapias in Taiwan. Fish Pathology 29, 61–71.CrossRefGoogle Scholar
  2. Gjessing, M.C., Inami, M., Weli, S.C., Ellingsen, T., Falk, K., Koppang, E.O. and Kvellestad, A. (2011) Presence and interaction of inflammatory cells in the spleen of Atlantic cod, Gadus morhua L., infected with Francisella noatunensis. Journal of Fish Diseases 34, 687–699.PubMedCrossRefGoogle Scholar
  3. Hollis, D.G., Weaver, R.E., Steigerwalt, A.G., Wenger, J.D., Moss, C.W. and Brenner, D.J. (1989) Francisella philomiragia comb. nov. (formerly Yersinia philomiragia) and Francisella tularensis biovar novicida (formerly Francisella novicida) associated with human disease. Journal of Clinical Microbiology 27, 1601–1608.PubMedGoogle Scholar
  4. Isachsen, C.H., Vågnes, Ø., Jakobsen, R.A. and Samuelsen, O.B. (2012) Antimicrobial susceptibility of Francisella noatunensis subsp. noatunensis strains isolated from Atlantic cod Gadus morhua in Norway. Diseases of Aquatic Organisms 98, 57–62.PubMedCrossRefGoogle Scholar
  5. Jeffrey, K.R., Stone, D., Feist, S.W. and Verner-Jeffrey, D.W. (2010) An outbreak of disease caused by Francisella sp. in Nile tilapia Oreochromis niloticus at a recirculation fish farm in the UK. Diseases of Aquatic Organisms 91, 161–165.CrossRefGoogle Scholar
  6. Jensen, W.I., Owen, C.R. and Jellison, W.J. (1969) Yersinia philomiragia sp. n., a new member of the Pasteurella group of bacteria, naturally pathogenic for the muskrat (Ondatra zibethica). Journal of Bacteriology 100, 1237–1241.PubMedGoogle Scholar
  7. Kamashi, T., Fukuda, Y., Nishiyama, M., Kawakami, H., Matsuyama, T., Yoshinaga, T. and Oseko, N. (2005) identification and pathogenicity of intracellular Francisella bacterium in three-line grunt Parapristipoma trilineatum. Fish Pathology 40, 67–71.CrossRefGoogle Scholar
  8. Kawanishi, M., Kojima, A., ishihara, K., Esaki, H., Kijima, M., Takahashi, T., Suzuki, S. and Tamura, Y. (2005) Drug resistance and pulsed-field gel electrophoresis patterns of Lactococcus garvieae isolates from cultured Seriola (yellowtail, amberjack and kingfish) in Japan. Letters in Applied Microbiology 40, 322–328.PubMedCrossRefGoogle Scholar
  9. Mikalsen, J., Olsen, A.B., Tengs, T. and Colquhoun, D.J. (2007) Francisella philomiragia subsp. noatunensis subsp. nov., isolated from farmed Atlantic cod (Gadus morhua L.). International Journal of Systematic and Evolutionary Microbiology 57, 1960–1965.PubMedCrossRefGoogle Scholar
  10. Mikalsen, J., Olsen, A.B., Rudra, H., Moldal, T., Lund, H., Djønne, B., Bergh, Ø, and Colquhoun, D.J. (2009) Virulence and pathogenicity of Francisella philomiragia subsp. noatunensis for Atlantic cod, Gadus morhua L., and laboratory mice. Journal of Fish Diseases 32, 377–381.PubMedCrossRefGoogle Scholar
  11. Mikalsen, J. and Colquhoun, D.J. (2010) Francisella asiatica sp. nov. isolated from farmed tilapia (Oreochromis sp.) and elevation of Francisella philomiragia subsp. noatunensis to species rank as Francisella noatunensis comb. nov., sp. nov. International Journal of Systematic and Evolutionary Microbiology 59, doi: ijs.0.002139-0.
  12. Olsen A.B., Mikalsen, J., Rode, M., Alfjorden, A., Hoel, E., Straum-Lie, K., Haldorsen, R. and Colquhoun, D.J. (2006) A novel systemic granulomatous inflammatory disease in farmed Atlantic cod, Gadus morhua L., associated with a bacterium belonging to the genus Francisella. Journal of Fish Diseases 29, 307–311.PubMedCrossRefGoogle Scholar
  13. Ostland, V.E., Stannard, J.A., Creek, J.J., Hedrick, R.P., Ferguson, H.W., Carlberg, J.M. and Westerman, M.E. (2006) Aquatic Francisella-like bacterium associated with mortalities of intensively cultured hybrid striped bass Morone chrysops x M. Saxatilis. Diseases of Aquatic Organisms 72, 135–145.PubMedCrossRefGoogle Scholar
  14. Ottem, K.F., Nylund, A., Isaksen, T.E., Karlsbakk, E. and Bergh, Ø. (2008) Occurrence of Frnacisella piscicida in farmed and wild Atlantic cod, Gadus morhua L., in Norway. Journal of Fish Diseases 31, 525–534.PubMedCrossRefGoogle Scholar
  15. Ritter, D.B. and Gerloff, R.K. (1966) Deoxyribonucleic acid hybridization among some species of the genus Pasteurella. Journal of Bacteriology 92, 1838–1939.PubMedGoogle Scholar
  16. Soto, E., Hawke, J.P., Fernandez, D. and Morales, J.A. (2009) Francisella sp., an emerging pathogen of tilapia, Oreochromis niloticus (L.), in Costa Rica. Journal of Fish Diseases 32, 713–722.PubMedCrossRefGoogle Scholar
  17. Soto, E., Bowles, K., Fernandez, D. and Hawke, J.P. (2010a) Development of a real-time PCR assay for identification and quantification of the fish pathogen Francisella noatunensis subsp orientalis. Diseases of Aquatic Organisms 89, 199–207.PubMedCrossRefGoogle Scholar
  18. Soto, E., Fernandez, D., Thune, R. and Hawke, J.P. (2010b) Interaction of Francisella asiatica with tilapia (Oreochromis niloticus) innate immunity. Infection and Immunity 78, 2070–2078.PubMedCrossRefGoogle Scholar
  19. Soto, E., Endris, R.G. and Hawke, J.P. (2010c) In vitro and in vivo efficacy of florfenicol for treatment of Francisella asiatica infection of tilapia. Antimicrobial Agents and Chemotherapy 54, 4664–4670.PubMedCrossRefGoogle Scholar
  20. Soto, E., Wiles, J., Elzer, P., Macaluso, K. and Hawke, J.P. (2011) Attenuated Francisella asiatica iglc mutant induces protective immunity to francisellosis in tilapia. Vaccine 29, 593–598.PubMedCrossRefGoogle Scholar
  21. Wangen, I.H., Karlsbakk, E., Einen, A.C.B., Ottem, K.F., Nylund, A. and Mortensen, S. (2012) Fate of Francisella noatunensis, a pathogen of Atlantic cod Gadus morhua, in blue mussels Mytilus edulis. Diseases of Aquatic Organisms 98, 63–72.PubMedCrossRefGoogle Scholar
  22. Zerihun, M.A., Feist, S.W., Bucke, D., Olsen, A.B., Tandstad, N.M. and Colquhoun, D.J. (2011c) Francisella noatunensis subsp. noatunensis is the aetiological agent of visceral granulomatosis in wild Atlantic cod Gadus morhua. Diseases in Aquatic Organisms 95, 65–71.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • Brian Austin
    • 1
  • Dawn A. Austin
    • 2
  1. 1.Institute of AquacultureUniversity of StirlingStirlingUK
  2. 2.School of Life SciencesHeriot-Watt UniversityEdinburghUK

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