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Human Mesenchymal Stem Cell Transdifferentiation to Neural Cells: Role of Tumor Necrosis Factor Alpha

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Stem Cells and Cancer Stem Cells, Volume 8

Part of the book series: Stem Cells and Cancer Stem Cells ((STEM,volume 8))

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Abstract

Mesenchymal stem cell (MSC)-based therapy is a promising new approach in regenerative medicine and anti-tumor strategies. The MSCs are easily accessible and can be rapidly expanded in vitro. Additionally, MSCs possess the useful characteristics of stem cell plasticity or transdifferentiation, cytokine/chemokine secretion, and tumor tropism. After in vivo administration, MSCs induce peripheral tolerance and migrate to sites of injury where they promote tissue repair and regeneration. Moreover, MSCs turned into a “Trojan horse” by introducing specific transgenes have potential as therapeutic vehicles to target aggressive inoperable tumors. Although local transplantation or injection of hMSCs may prove therapeutically useful, the ability to target MSCs to specific tissues with high efficiency will be crucial in developing new treatments. This article introduces MSCs as multipotent and multifunctional cells, addresses especially the properties of MSCs transdifferentiated by tumor necrosis factor (TNF-)α into neural cells, and discusses the potential of MSC-based strategies in the therapy of neurodegenerative diseases and injuries of the central nervous system.

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Authors and Affiliations

  1. Institute for Cardiovascular Prevention, Ludwig Maximilians-University of Munich, Pettenkoferstrasse 9b, 80336, Munich, Germany

    Christian Ries & Virginia Egea

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  1. Christian Ries
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  2. Virginia Egea
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Correspondence to Christian Ries .

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Editors and Affiliations

  1. Biology, Kean University, Union, New Jersey, USA

    M.A. Hayat

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Ries, C., Egea, V. (2012). Human Mesenchymal Stem Cell Transdifferentiation to Neural Cells: Role of Tumor Necrosis Factor Alpha. In: Hayat, M. (eds) Stem Cells and Cancer Stem Cells, Volume 8. Stem Cells and Cancer Stem Cells, vol 8. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4798-2_7

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