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Cellular Trafficking of Cell Stress Proteins in Health and Disease pp 29–42Cite as

Molecular Chaperones and Protein-Folding Catalysts in Biological Fluids

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Part of the book series: Heat Shock Proteins ((HESP,volume 6))

Abstract

Although yet to be fully accepted by the wider scientific community, it is clear that heat shock (stress) proteins can be released from a number of different cell types via mechanisms that do not involve overt cell death. These proteins have now been found in a number of biological fluids, in which they have the potential to elicit a range of essential functions. This chapter summarises elements of the current literature relating to the presence of heat shock proteins that have been found in biological fluids and highlights the role(s) of these, as appropriate. Although much progress has been made, we need to better structure our studies in order to provide more informative insights into the functions of these proteins and perhaps consider their presence in a broader context which involves the application of Systems Biology principles. It is likely that heat shock protein profiling will provide more insight into the physiological significance of these multifunctional proteins, the sequence conservation of which illustrates their importance to organismal regulation and homeostasis.

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  1. John van Geest Cancer Research Centre, Nottingham Trent University, Clifton Lane, NG11 8NS, Nottingham, UK

    A. Graham Pockley

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  1. Eastman Dental Institute, Div. Microbial Diseases, University College, London, Gray's Inn Road 256, London, WC1X 8LD, United Kingdom

    Brian Henderson

  2. School of Medicine & Biomedical Science, University of Sheffield, Beech Hill Road, Sheffield, S10 2RX, United Kingdom

    A. Graham Pockley

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Pockley, A. (2012). Molecular Chaperones and Protein-Folding Catalysts in Biological Fluids. In: Henderson, B., Pockley, A. (eds) Cellular Trafficking of Cell Stress Proteins in Health and Disease. Heat Shock Proteins, vol 6. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4740-1_3

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