Abstract
Surprisingly, the history of the agonist actions of extracellular molecular chaperones can be traced back to the 1970s, with the cytokine macrophage migration inhibitory factor (MIF) and chaperonin (Hsp)10. The next cell stress protein to be identified as a molecular chaperone was the peptidylprolyl isomerase, cyclophilin A, in 1992. It is only later in the 1990s that the major signalling cell stress proteins—chaperonin (Hsp)60 and Hsp70 are found to have agonist activities. There are still ongoing discoveries of stress proteins with agonist actions and the latest such proteins are a new group of molecular chaperones—the extracellular/circulating molecular chaperones which include clusterin and α-acid1-glycoprotein.
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Henderson, B. (2012). Discovery of the Extracellular Agonist Actions of Molecular Chaperones and Protein-Folding Catalysts. In: Henderson, B., Pockley, A. (eds) Cellular Trafficking of Cell Stress Proteins in Health and Disease. Heat Shock Proteins, vol 6. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4740-1_2
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