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Circulating Chaperones in Health and Disease

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Cellular Trafficking of Cell Stress Proteins in Health and Disease

Part of the book series: Heat Shock Proteins ((HESP,volume 6))

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Abstract

Heat-shock proteins (HSPs), released from living or dying cells by active and passive mechanisms, are present in the circulation of healthy individuals and patients with different diseases. Recent clinical studies provided evidence for circulating HSPs as promising biomarkers of inflammation, infection, cellular damage and in different forms of cardiovascular disease. The group of malignant human diseases represents probably the most important research area today to find the clinical utility of measuring circulating HSP70 levels. This chapter summarizes observational human clinical studies of this HSP-biomarker field with major emphasis on circulating stress-inducible HSP70 (HSPA1A).

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Acknowledgement

The author of this chapter expresses his gratitude thanks to Professor George Füst for his stimulating discussions and continuous support on studies with extracellular heat-shock proteins, and to Szigeti Antalné and Márta Kókai for expert technical support in the last years.

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Authors and Affiliations

  1. Research Laboratory, 3rd Department of Medicine, Semmelweis University, Kútvölgyi st. 4, 1125, Budapest, Hungary

    Zoltán Prohászka M.D. D.Sc.

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  1. Zoltán Prohászka M.D. D.Sc.
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Correspondence to Zoltán Prohászka M.D. D.Sc. .

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Editors and Affiliations

  1. Eastman Dental Institute, Div. Microbial Diseases, University College, London, Gray's Inn Road 256, London, WC1X 8LD, United Kingdom

    Brian Henderson

  2. School of Medicine & Biomedical Science, University of Sheffield, Beech Hill Road, Sheffield, S10 2RX, United Kingdom

    A. Graham Pockley

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Prohászka, Z. (2012). Circulating Chaperones in Health and Disease. In: Henderson, B., Pockley, A. (eds) Cellular Trafficking of Cell Stress Proteins in Health and Disease. Heat Shock Proteins, vol 6. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4740-1_18

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