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The Chaperokine Activity of HSPA1A

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Cellular Trafficking of Cell Stress Proteins in Health and Disease

Part of the book series: Heat Shock Proteins ((HESP,volume 6))

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Abstract

There is a dichotomy between the intracellular and extracellular effector functions of HSPA1A. The enhanced expression of intracellular HSPA1A primarily promotes protein chaperoning, transport and folding of naïve, aberrantly folded, or mutated proteins, resulting in cytoprotection when cells are exposed to a variety of stressful stimuli. In contrast, exposure of immunocompetent cells to extracellular HSPA1A activates antigen presenting cell-mediated effectors functions; including enhanced pro-inflammatory and anti-inflammatory responses, chemokine and co-stimulatory molecule expression and in anti-tumor surveillance. In addition, extracellular HSPA1A has been shown to play a role in situations of acute psychological stress and exercise. This chapter covers recent advances in understanding the complex nature of extracellular HSPA1A and briefly discusses the biological significance of circulating serum HSPA1A to host physiology and includes recent application of HSPA1A-based immunotherapies.

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Acknowledgements

We thank Princess Bempong, Shahrum Lillard and Viraj Mehta for expert technical assistance, and all the faculty and staff members of the Division of Investigative Pathology for helpful discussions. This work was supported in part a Research Advancement Award from Scott & White Memorial Hospital and Clinic (to P.K.), the US National Institutes of Health grant RO1CA91889, Scott & White Hospital and Clinic, the Texas A&M Health Science Center College of Medicine, the Central Texas Veterans Health Administration and an Endowment from the Cain Foundation (to A.A.). The funders had no role in study design, data collection and analysis, decision to publish or preparation of the chapter.

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  1. Department of Microbiology, Biochemistry and Immunology (MBI), Morehouse School of Medicine, 720 Westview Ave., 30310, Atlanta, GA, SW, USA

    Alexzander Asea & Punit Kaur

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  1. Alexzander Asea
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  2. Punit Kaur
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Correspondence to Alexzander Asea .

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  1. Eastman Dental Institute, Div. Microbial Diseases, University College, London, Gray's Inn Road 256, London, WC1X 8LD, United Kingdom

    Brian Henderson

  2. School of Medicine & Biomedical Science, University of Sheffield, Beech Hill Road, Sheffield, S10 2RX, United Kingdom

    A. Graham Pockley

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Asea, A., Kaur, P. (2012). The Chaperokine Activity of HSPA1A. In: Henderson, B., Pockley, A. (eds) Cellular Trafficking of Cell Stress Proteins in Health and Disease. Heat Shock Proteins, vol 6. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4740-1_13

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