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Telomerase: Basic and Clinical Approaches

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Abstract

Telomerase enzyme is responsible for compensating telomere shortening occurred during cell proliferation and found to be reactivated in about 90 % of tumor cells. Telomerase activation could be regulated in two manners, including pretranslation and posttranslation. Some proteins including Akt kinase, PKC, and IP6 could induce telomerase activity. However, it may be suppressed by another group including c-Abl, and PP2A. In this chapter, some fundamental elements were highlighted. Furthermore, within a clinical based data, telomerase activity and expression of its RNA component; expression of hTR and hTERT in human primary breast cancer patients were discussed.

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Authors and Affiliations

  1. Medical Genetics Lab., Imam Hospital, Department of Genetics, Ardabil University of Medical Sciences, Ardabil, Iran

    S. Saied Hosseini-Asl

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  1. S. Saied Hosseini-Asl
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Correspondence to S. Saied Hosseini-Asl .

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Editors and Affiliations

  1. School Of Medicine, Tehran University of Medical Sciences, Department of Medical Genetics, Pour Sina Avenue, Tehran, 1417613151, Iran

    Parvin Mehdipour

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Hosseini-Asl, S. (2013). Telomerase: Basic and Clinical Approaches. In: Mehdipour, P. (eds) Telomere Territory and Cancer. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4632-9_2

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