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Changing Long-Held Beliefs Is Never Easy: A Proposal for Multimodal Approaches in Female Healthcare – An Integrative View

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Healthcare Overview

Part of the book series: Advances in Predictive, Preventive and Personalised Medicine ((APPPM,volume 1))

Abstract

Female health possesses its gender-specific attributes to be considered for effective healthcare performance. Common risk factors moderating the outcomes in the most frequent female pathologies, namely CVD, breast cancer and DM type 2 are progressing age, overweight, poor diet, physical inactivity and depression. Due to typical for twenty-first century demographic trends in favour of elderly populations, co-morbidities and more complex clinical situations now should be considered as the persistent challenge in healthcare that requires new strategies for improved treatment regiments.

Modifiable risk factors persist from childhood and adolescence into adulthood and tend to cluster with synergistic negative effects for consequent manifestation of co-morbid pathologies. Integrative medical approaches are strongly desirable to analyse common risk factors as well as their individual and synergistic effects. Thoroughly prepared patient profiling is essential for targeted prevention and advanced treatment regiments tailored to the patient. The performance of gender-specific multimodal approaches will sufficiently advance healthcare in favour of tailored treatments and individualised care. However, new guidelines should be essentially introduced to regulate the process of reconsideration of current strategies in healthcare.

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References

  1. Pilote L, Dasgupta K, Guru V, Humphries KH, McGrath J, Norris C, Rabi D, Tremblay J, Alamian A, Barnett T, Cox J, Ghali WA, Grace S, Hamet P, Ho T, Kirkland S, Lambert M, Libersan D, O’Loughlin J, Paradis G, Petrovich M, Tagalakis V (2007) A comprehensive view of sex-specific issues related to cardiovascular disease. CMAJ 176:1–44. doi:10.1503/cmaj.051455

    Google Scholar 

  2. World Health Organization (2006) Changes in death rates from CHD, men and women aged 35–74, between 1990 and 2000, selected countries. [Web site of the British Heart Foundation]. www.heartstats.org/temp/Figsp1.5bspweb06.xls

  3. Yeghiazaryan K, Bauriedel G, Schild HH, Golubnitschaja O (2008) Prediction of degeneration of native and bioprosthetic aortic valves: issue-related particularities of Diabetes mellitus. Infect Disord Drug Targets 8:88–99

    Article  PubMed  CAS  Google Scholar 

  4. Yeghiazaryan K, Skowasch D, Bauriedel G, Schild HH, Golubnitschaja O (2009) Prediction of degeneration of native and bioprosthetic aortic valves. In: Golubnitschaja O (ed) Predictive diagnostics and personalized treatment: dream or reality. Nova Science Publishers Inc., New York

    Google Scholar 

  5. Yeghiazaryan K, Skowasch D, Bauriedel G, Schild H, Golubnitschaja O (2011) Degenerative valve disease and bioprostheses: risk assessment, predictive diagnosis, personalised treatments. EPMA J 2(1):91–105. doi:10.1007/s13167-011-0072-3

    Article  Google Scholar 

  6. Heart and Stroke Foundation of Canada (1999) The changing face of heart disease and stroke in Canada 2000. Heart and Stroke Foundation, Ottawa. http://www.statcan.gc.ca/pub/82f0076x/4227745-eng.pdf. Accessed 27 Dec 2011

  7. Wolinsky FD, Wyrwich KW, Gurney JG (1999) Gender differences in the sequelae of hospitalization for acute myocardial infarction among older adults. J Am Geriatr Soc 47:151–158

    PubMed  CAS  Google Scholar 

  8. Wolf PA, Mitchell JB, Baker CS, Kannel WB, D’Agostino RB (1998) Impact of atrial fibrillation on mortality, stroke, and medical costs. Arch Intern Med 158:229–234

    Article  PubMed  CAS  Google Scholar 

  9. Humphries KH, Jackevicius C, Gong Y, Svensen L, Cox J, Tu JV, Laupacis A, Canadian Cardiovascular Outcomes Research Team (2004) Population rates of hospitalization for atrial fibrillation/flutter in Canada. Can J Cardiol 20:869–876

    PubMed  Google Scholar 

  10. Koelling TM, Chen RS, Lubwama RN, L’Italien GJ, Eagle KA (2004) The expanding national burden of heart failure in the United States: the influence of heart failure in women. Am Heart J 147:74–78. doi:10.1016/j.ahj.2003.07.021

    Article  PubMed  CAS  Google Scholar 

  11. Philbin EF, DiSalvo TG (1998) Influence of race and gender on care process, resource use, and hospital-based outcomes in congestive heart failure. Am J Cardiol 82:76–81

    Article  PubMed  CAS  Google Scholar 

  12. Yeghiazaryan K, Flammer J, Golubnitschaja O (2010) Predictive molecular profiling in blood of healthy vasospastic individuals: clue to targeted prevention as personalised medicine to effective costs. EPMA J 1(2):263–272. doi:10.1007/s13167-010-0032-3

    Article  Google Scholar 

  13. McSweeney JC, Cody M, Crane PB (2001) Do you know them when you see them? Women’s prodromal and acute symptoms of myocardial infarction. J Cardiovasc Nurs 15:26–38

    PubMed  CAS  Google Scholar 

  14. DeVon HA, Zerwic JJ (2002) Symptoms of acute coronary syndromes: are there gender differences? A review of the literature. Heart Lung 31:235–245. doi:10.1067/mhl.2002.126105

    Article  PubMed  Google Scholar 

  15. DeVon HA, Zerwic JJ (2003) The symptoms of unstable angina: do women and men differ? Nurs Res 52:108–118

    Article  PubMed  Google Scholar 

  16. McSweeney JC, Cody M, O’Sullivan P, Elberson K, Moser DK, Garvin BJ (2003) Women’s early warning symptoms of acute myocardial infarction. Circulation 108:2619–2623. doi:10.1161/01.CIR.0000097116.29625.7C

    Article  PubMed  Google Scholar 

  17. Méthot J, Hamelin BA, Bogaty P, Arsenault M, Plante S, Poirier P (2004) Does hormonal status influence the clinical presentation of acute coronary syndromes in women? J Womens Health (Larchmt) 13:695–702. doi:10.1089/jwh.2004.13.695

    Article  Google Scholar 

  18. Kimble LP, McGuire DB, Dunbar SB, Fazio S, De A, Weintraub WS, StricklandOS (2003) Gender differences in pain characteristics of chronic stable angina andperceived physical limitation in patients with coronary artery disease. Pain 101:45–53. doi:10.1016/S0304-3959(02)00319-6

    Article  PubMed  Google Scholar 

  19. Bahr R, Christenson R, Farin H, Hand M, Long JM (2001) Prodromal symptoms of acute myocardial infarction: overview of evidence. Md Med 2(Suppl):49–59

    Google Scholar 

  20. Williams RI, Fraser AG, West RR (2004) Gender differences in management after acute myocardial infarction: not‚ sexism’ but a reflection of age at presentation. J Public Health (Oxf) 26:259–263. doi:10.1093/pubmed/fdh159

    Article  Google Scholar 

  21. Bakler T, Baburin A, Teesalu R, Rahu M (2004) Comparison of management and 30-day mortality of acute myocardial infarction in men versus women in Estonia. Acta Cardiol 59:275–281. doi:10.2143/AC.59.3.2005182

    Article  PubMed  Google Scholar 

  22. Zubaid M, Rashed WA, Thalib L, Suresh CG (2001) Differences in thrombolytic treatment and in-hospital mortality between women and men after acute myocardial infarction. Jpn Heart J 42:669–676

    Article  PubMed  CAS  Google Scholar 

  23. Jackevicius CA, Alter D, Cox J, Daly P, Goodman S, Filate W, Newman A, Tu JV, Canadian Cardiovascular Outcomes Research Team (2005) Acute treatment of myocardial infarction in Canada 1999–2002. Can J Cardiol 21:145–152

    PubMed  Google Scholar 

  24. Theres H, Maier B, Matteucci Gothe R, Schnippa S, Kallischnigg G, Schüren KP, Thimme W; Berliner Herzinfarktregister e.V. (2004) Influence of gender on treatment and short-term mortality of patients with acute myocardial infarction in Berlin. Z Kardiol 93:954–963. doi:10.1007/s00392-004-0157-2

    Article  PubMed  CAS  Google Scholar 

  25. Martínez-Sellés M, López-Palop R, Pérez-David E, Bueno H (2005) Influence of age on gender differences in the management of acute inferior or posterior myocardial infarction. Chest 128:792–797. doi:10.1378/chest.128.2.792

    Article  PubMed  Google Scholar 

  26. Heer T, Schiele R, Schneider S, Gitt AK, Wienbergen H, Gottwik M, Gieseler U, Voigtländer T, Hauptmann KE, Wagner S, Senges J (2002) Gender differences in acute myocardial infarction in the era of reperfusion (the MITRA registry). Am J Cardiol 89:511–517. doi:10.1016/S0002-9149(01)02289-5

    Article  PubMed  Google Scholar 

  27. Carrabba N, Santoro GM, Balzi D, Barchielli A, Marchionni N, Fabiani P, Landini C, Scarti L, Santoro G, Valente S, Verdiani V, Buiatti E, AMI-Florence Working Group (2004) In-hospital management and outcome in women with acute myocardial infarction (data from the AMI-Florence Registry). Am J Cardiol 94:1118–1123. doi:10.1016/j.amjcard.2004.07.076

    Article  PubMed  Google Scholar 

  28. de Gevigney G, Mosnier S, Ecochard R, Rabilloud M, Cao D, Excoffier S, Cheneau E, Milon H, Delahaye F, PRIMA Group (2001) Are women with acute myocardial infarction managed as well as men? Does it have consequences on in-hospital mortality? Analysis of an unselected cohort of 801 women and 1,718 men. Acta Cardiol 56:169–179

    Article  PubMed  Google Scholar 

  29. Lefler LL, Bondy KN (2004) Women’s delay in seeking treatment with myocardial infarction: a meta-synthesis. J Cardiovasc Nurs 19:251–268

    PubMed  Google Scholar 

  30. Goldberg R, Goff D, Cooper L, Luepker R, Zapka J, Bittner V, Osganian S, Lessard D, Cornell C, Meshack A, Mann C, Gilliland J, Feldman H (2000) Age and sex differences in presentation of symptoms among patients with acute coronary disease: the REACT trial. Coron Artery Dis 11:399–407

    Article  PubMed  CAS  Google Scholar 

  31. Kannel WB, Abbott RD (1984) Incidence and prognosis of unrecognized myocardial infarction. An update on the Framingham study. N Engl J Med 311:1144–1147

    Article  PubMed  CAS  Google Scholar 

  32. Hochman JS, Tamis JE, Thompson TD, Weaver WD, White HD, Van de Werf F, Aylward P, Topol EJ, Califf RM (1999) Sex, clinical presentation, and outcome in patients with acute coronary syndromes. Global use of strategies to open occluded coronary arteries in acute coronary syndromes IIb investigators. N Engl J Med 341:226–232

    Article  PubMed  CAS  Google Scholar 

  33. Vaccarino V, Abramson JL, Veledar E, Weintraub WS (2002) Sex differences in hospital mortality after coronary artery bypass surgery: evidence for a higher mortality in younger women. Circulation 105:1176–1181. doi:10.1161/hc1002.105133

    Article  PubMed  Google Scholar 

  34. White HD, Barbash GI, Modan M, Simes J, Diaz R, Hampton JR, Heikkilä J, Kristinsson A, Moulopoulos S, Paolasso EA et al (1993) After correcting for worse baseline characteristics, women treated with thrombolytic therapy for acute myocardial infarction have the same mortality and morbidity as men except for a higher incidence of hemorrhagic stroke. The investigators of the international tissue plasminogen activator/streptokinase mortality study. Circulation 88:2097–2103. doi:10.1161/01.CIR.88.5.2097

    Article  PubMed  CAS  Google Scholar 

  35. Stone GW, Grines CL, Browne KF, Marco J, Rothbaum D, O’Keefe J, Hartzler GO, Overlie P, Donohue B, Chelliah N et al (1995) Comparison of in-hospital outcome in men versus women treated by either thrombolytic therapy or primary coronary angioplasty for acute myocardial infarction. Am J Cardiol 75:987–992

    Article  PubMed  CAS  Google Scholar 

  36. Weaver WD, White HD, Wilcox RG, Aylward PE, Morris D, Guerci A, Ohman EM, Barbash GI, Betriu A, Sadowski Z, Topol EJ, Califf RM (1996) Comparisons of characteristics and outcomes among women and men with acute myocardial infarction treated with thrombolytic therapy. GUSTO-I investigators. JAMA 275:777–782

    Article  PubMed  CAS  Google Scholar 

  37. Køber L, Torp-Pedersen C, Ottesen M, Rasmussen S, Lessing M, Skagen K (1996) Influence of gender on short-and long-term mortality after acute myocardial infarction. TRACE study group. Am J Cardiol 77:1052–1056

    Article  PubMed  Google Scholar 

  38. Malacrida R, Genoni M, Maggioni AP, Spataro V, Parish S, Palmer A, Collins R, Moccetti T (1998) A comparison of the early outcome of acute myocardial infarction in women and men. The third international study of infarct survival collaborative group. N Engl J Med 338:8–14

    Article  PubMed  CAS  Google Scholar 

  39. Gottlieb S, Harpaz D, Shotan A, Boyko V, Leor J, Cohen M, Mandelzweig L, Mazouz B, Stern S, Behar S (2000) Sex differences in management and outcome after acute myocardial infarction in the 1990s: a prospective observational community-based study. Israeli thrombolytic survey group. Circulation 102:2484–2490. doi:10.1161/01.CIR.102.20.2484

    Article  PubMed  CAS  Google Scholar 

  40. Vaccarino V, Krumholz HM, Berkman LF, Horwitz RI (1995) Sex differences in mortality after myocardial infarction. Is there evidence for an increased risk for women? Circulation 91:1861–1871. doi:10.1161/01.CIR.91.6.1861

    Article  PubMed  CAS  Google Scholar 

  41. Tu JV, Austin PC, Filate WA, Johansen HL, Brien SE, Pilote L, Alter DA, Canadian Cardiovascular Outcomes Research Team (2003) Outcomes of acute myocardial infarction in Canada. Can J Cardiol 19:893–901

    PubMed  Google Scholar 

  42. Jamal SM, Shrive FM, Ghali WA, Knudtson ML, Eisenberg MJ, Canadian Cardiovascular Outcomes Research Team (CCORT) (2003) In-hospital outcomes after percutaneous coronary intervention in Canada: 1992/93 to 2000/01. Can J Cardiol 19:782–789

    PubMed  Google Scholar 

  43. Edwards FH, Ferraris VA, Shahian DM, Peterson E, Furnary AP, Haan CK, Bridges CR, Society of Thoracic Surgeons (2005) Gender-specific practice guidelines for coronary artery bypass surgery: perioperative management. Ann Thorac Surg 79:2189–2194. doi:10.1016/j.athoracsur.2005.02.065

    Article  PubMed  Google Scholar 

  44. Lansky AJ, Hochman JS, Ward PA, Mintz GS, Fabunmi R, Berger PB, New G, Grines CL, Pietras CG, Kern MJ, Ferrell M, Leon MB, Mehran R, White C, Mieres JH, Moses JW, Stone GW, Jacobs AK, American College of Cardiology Foundation; American Heart Association (2005) Percutaneous coronary intervention and adjunctive pharmacotherapy in women: a statement for healthcare professionals from the American Heart Association. Circulation 111:940–953. doi:10.1161/01.CIR.0000155337.50423.C9

    Article  PubMed  Google Scholar 

  45. Cebioglu M, Schild HH, Golubnitschaja O (2010) Cancer predisposition in diabetics: risk factors considered for predictive diagnostics and targeted preventive measures. EPMA J 1(1):130–137. doi:10.1007/s13167-010-0015-4

    Article  Google Scholar 

  46. Inoue M, Iwasaki M, Otani T, Sasazuki S, Noda M, Tsugane S (2006) Diabetes mellitus and the risk of cancer: results from a large-scale population-based cohort study in Japan. Arch Intern Med 166:1871–1877

    Article  PubMed  Google Scholar 

  47. Pronk NP, Anderson LH, Crain AL, Martinson BC, O’Connor PJ, Sherwood NE, Whitebird RR (2004) Meeting recommendations for multiple healthy lifestyle factors. Prevalence, clustering, and predictors among adolescent, adult, and senior health plan members. Am J Prev Med 27:25–33. doi:10.1016/j.amepre.2004.04.022

    Article  PubMed  Google Scholar 

  48. Cummings SR, Tice JA, Bauer S, Browner WS, Cuzick J, Ziv E, Vogel V, Shepherd J, Vachon C, Smith-Bindman R, Kerlikowske K (2009) Prevention of breast cancer in postmenopausal women: approaches to estimating and reducing risk. J Natl Cancer Inst 101:384–398. doi:10.1093/jnci/djp018

    Article  PubMed  Google Scholar 

  49. Thompson A, Brennan K, Cox A, Gee J, Harcourt D, Harris A, Harvie M, Holen I, Howell A, Nicholson R, Steel M, Streuli C (2008) Evaluation of the current knowledge limitations in breast cancer research: a gap analysis. Breast Cancer Res 10:R26. doi:10.1186/bcr1983

    Article  PubMed  Google Scholar 

  50. Janz KF, Dawson JD, Mahoney LT (2000) Tracking physical fitness and physical activity from childhood to adolescence: the muscatine study. Med Sci Sports Exerc 32:1250–1257

    Article  PubMed  CAS  Google Scholar 

  51. Bao W, Threefoot SA, Srinivasan SR, Berenson GS (1995) Essential hypertension predicted by tracking of elevated blood pressure from childhood to adulthood: the Bogalusa heart study. Am J Hypertens 8:657–665. doi:10.1016/0895-7061(95)00116-7

    Article  PubMed  CAS  Google Scholar 

  52. Guo SS, Huang C, Maynard LM, Demerath E, Towne B, Chumlea WC, Siervogel RM (2000) Body mass index during childhood, adolescence, and young adulthood in relation to adult overweight and adiposity: the Fels longitudinal study. Int J Obes Relat Metab Disord 24:1628–1635

    Article  PubMed  CAS  Google Scholar 

  53. Nicklas TA, von Duvillard SP, Berenson GS (2002) Tracking of serum lipids and lipoproteins from childhood to dyslipidemia in adults: the Bogalusa heart study. Int J Sports Med 23(suppl 1):S39–S43. doi:10.1055/s-2002-28460

    Article  PubMed  Google Scholar 

  54. (1999) Canadian Cardiovascular Society 1998 consensus conference on the prevention of cardiovascular diseases: the role of the cardiovascular specialist. Can J Cardiol 15(Suppl G):1G–119G

    Google Scholar 

  55. Raitakari OT, Porkka KV, Räsänen L, Viikari JS (1994) Relations of life-style with lipids, blood pressure and insulin in adolescents and young adults. The cardiovascular risk in young Finns study. Atherosclerosis 111:237–246

    Article  PubMed  CAS  Google Scholar 

  56. Bergström E, Hernell O, Persson LA (1996) Cardiovascular risk indicators cluster in girls from families of low socio-economic status. Acta Paediatr 85:1083–1090. doi:10.1111/j.1651-2227.1996.tb14222.x

    Article  PubMed  Google Scholar 

  57. Pate RR, Heath GW, Dowda M, Trost SG (1996) Associations between physical activity and other health behaviors in a representative sample of US adolescents. Am J Public Health 86:1577–1581. doi:10.2105/AJPH.86.11.1577

    Article  PubMed  CAS  Google Scholar 

  58. McKenna M, Taylor W, Marks J, Koplan J (1998) Current issues and challenges in chronic disease control. In: Brownson R, Remington P, Davis J (eds) Chronic disease epidemiology and control. American Public Health Association/United Book Press, Washington, DC

    Google Scholar 

  59. Harrison TR, Fauci AS (1998) Health professions division. In: Harrison’s principles of internal medicine, vol 14. McGraw-Hill, New York

    Google Scholar 

  60. Ahern TP, Lash TL, Sørensen HT, Pedersen L (2008) Digoxin treatment is associated with an increased incidence of breast cancer: a population-based case-control study. Breast Cancer Res 10:R102. doi:10.1186/bcr2205

    Article  PubMed  Google Scholar 

  61. Haux J, Klepp O, Spigset O, Tretli S (2001) Digitoxin medication and cancer; case control and internal dose-response studies. BMC Cancer 1:11. doi:10.1186/1471-2407-1-11

    Article  PubMed  CAS  Google Scholar 

  62. Ewertz M, Holmberg L, Tretli S, Pedersen BV, Kristensen A (2001) Risk factors for male breast cancer – a case-control study from Scandinavia. Acta Oncol 40:467–471. doi:10.1080/028418601750288181

    Article  PubMed  CAS  Google Scholar 

  63. Hayward RA, Krumholz HM (2012) Three reasons to abandon low-density lipoprotein targets – an open letter to the adult treatment panel IV of the National Institute of Health. Circulation 5:2–5

    PubMed  Google Scholar 

  64. Golubnitschaja O, Costigliola V, EPMA (2012) General Report & Recommendations in Predictive, Preventive and Personalised Medicine 2012: White Paper of the European Association for Predictive, Preventive and Personalised Medicine. EPMA J, in print

    Google Scholar 

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  1. Molecular Diagnostics, Radiological Clinic, Medical Faculty, Friedrich-Wilhelms-University of Bonn, Bonn, Germany

    Olga Golubnitschaja

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    Vincenzo Costigliola

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Golubnitschaja, O. (2012). Changing Long-Held Beliefs Is Never Easy: A Proposal for Multimodal Approaches in Female Healthcare – An Integrative View. In: Costigliola, V. (eds) Healthcare Overview. Advances in Predictive, Preventive and Personalised Medicine, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4602-2_14

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