Dose Dependent Effect of Progesterone on Hypoxic Ventilatory Response in Newborn Rats

  • Oubeidallah Hichri
  • Jean-C Laurin
  • Cécile A. Julien
  • Vincent Joseph
  • Aida BairamEmail author
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 758)


The effect of progesterone as a respiratory stimulant in newborn subjects is less known than that in adults. This study investigated the dose-response curve (0, 2, 4, and 8 mg/kg, ip) of progesterone on ventilation in non-anesthetized newborn rats at 4- and 12-days old using plethysmo­graphy. Progesterone had no effects in the regulation of normoxic ventilation. However, it enhanced the response to moderate hypoxia (FiO2 12%, 20 min) in 4- but not in 12-days old pups. This response was similar between the dose of 4 and 8 mg/kg. These observations suggested that progesterone enhances in age- and dose-dependent manner the hypoxic ventilatory response in newborn rats.


Hypoxia Progesterone Newborn rat 


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Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • Oubeidallah Hichri
    • 1
  • Jean-C Laurin
    • 1
  • Cécile A. Julien
    • 1
  • Vincent Joseph
    • 1
    • 2
  • Aida Bairam
    • 1
    • 3
    Email author
  1. 1.Unité de Recherche en Périnatologie, Département de PédiatrieCentre Hospitalier Universitaire de Québec, Hôpital Saint-François d’Assise, Université LavalQuébecCanada
  2. 2.CRCHUQ/Hop LavalQuébecCanada
  3. 3.Centre de Recherche, D0-717, Hôpital Saint-François d’AssiseQuébecCanada

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