Brain-Derived Neurotrophic Factor in the Nucleus Tractus Solitarii Modulates Glucose Homeostasis After Carotid Chemoreceptor Stimulation in Rats

  • Sergio Montero
  • Ricardo Cuéllar
  • Mónica Lemus
  • Reyes Ávalos
  • Gladys Ramírez
  • Elena Roces de Álvarez-BuyllaEmail author
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 758)


Neuronal systems, which regulate energy intake, energy expenditure and endogenous glucose production, sense and respond to input from hormonal related signals that convey information from body energy availability. Carotid chemoreceptors (CChr) function as sensors for circulating glucose levels and contribute to glycemic counterregulatory responses. Brain-derived neurotrophic factor (BDNF) that plays an important role in the endocrine system to regulate glucose metabolism could play a role in hyperglycemic glucose reflex with brain glucose retention (BGR) evoked by anoxic CChr stimulation. Infusing BDNF into the nucleus tractus solitarii (NTS) before CChr stimulation, showed that this neurotrophin increased arterial glucose and BGR. In contrast, BDNF receptor (TrkB) antagonist (K252a) infusions in NTS resulted in a decrease in both glucose variables.


BDNF NTS Brain glucose retention Carotid chemoreceptor stimulation 



Supporte by FRABA 330/205 and CONACYT P49376-Q grants.


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Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • Sergio Montero
    • 1
    • 2
  • Ricardo Cuéllar
    • 1
  • Mónica Lemus
    • 1
  • Reyes Ávalos
    • 2
  • Gladys Ramírez
    • 2
  • Elena Roces de Álvarez-Buylla
    • 1
    Email author
  1. 1.Centro Universitario de Investigaciones BiomédicasUniversidad de ColimaColimaMexico
  2. 2.Facultad de MedicinaUniversidad de ColimaColimaMexico

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