Advertisement

Neonatal Intermittent Hypoxia Induces Persistent Alteration of Baroreflex in Adult Male Rats

  • Cécile A. JulienEmail author
  • Richard Kinkead
  • Vincent Joseph
  • Aida Bairam
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 758)

Abstract

Baroreflex is involved in the regulation of arterial blood pressure (BP). An increase in BP activates vagal inhibitory pathways to decrease heart rate; a concomitant decrease in sympathetic discharge reduces vascular resistance. Both responses reduce BP towards normal value. Conversely, a decrease in BP produces opposite effects to increase heart rate and vascular resistance.

Keywords

Neonatal apnea Cardiovascular regulation 

Notes

Acknowledgments

We acknowledge Van Diep Doan for technical assistance, Melanie Pelletier, Sylvie Vigier, and Evelyne Vachon for animal care. Supported by grants from The Hospital for Sick Children’s Foundation/Canadian institute on Health Research (Grant #XG07-006), Réseau en Santé Respiratoire du FRSQ.

References

  1. Carlson JT, Hedner JA, Sellgren J, Elam M, Wallin BG (1996) Depressed baroreflex sensitivity in patients with obstructive sleep apnea. Am J Respir Crit Care Med 154:1490–1496PubMedGoogle Scholar
  2. Dematteis M, Julien C, Guillermet C, Sturm N, Lantuejoul S, Mallaret M, Levy P, Gozal E (2008) Intermittent hypoxia induces early functional cardiovascular remodeling in mice. Am J Respir Crit Care Med 177:227–235PubMedCrossRefGoogle Scholar
  3. Fletcher EC (2001) Invited review: Physiological consequences of intermittent hypoxia: systemic blood pressure. J Appl Physiol 90:1600–1605PubMedCrossRefGoogle Scholar
  4. Imadojemu VA, Gleeson K, Quraishi SA, Kunselman AR, Sinoway LI, Leuenberger UA (2002) Impaired vasodilator responses in obstructive sleep apnea are improved with continuous positive airway pressure therapy. Am J Respir Crit Care Med 165:950–953PubMedGoogle Scholar
  5. Julien C, Sam B, Patrick L (2003) Vascular reactivity to norepinephrine and acetylcholine after chronic intermittent hypoxia in mice. Respir Physiol Neurobiol 139:21–32PubMedCrossRefGoogle Scholar
  6. Julien CA, Niane LM, Kinkead R, Bairam A, Joseph V (2010) Carotid sinus nerve stimulation, but not intermittent hypoxia, induces respiratory LTF in adult rats exposed to neonatal intermittent hypoxia. Am J Physiol Regul Integr Comp Physiol 299(1):R192–205Google Scholar
  7. Leung RS, Bradley TD (2001) Sleep apnea and cardiovascular disease. Am J Respir Crit Care Med 164:2147–2165PubMedGoogle Scholar
  8. Soukhova-O’Hare GK, Cheng ZJ, Roberts AM, Gozal D (2006) Postnatal intermittent hypoxia alters baroreflex function in adult rats. Am J Physiol Heart Circ Physiol 290:H1157–1164PubMedCrossRefGoogle Scholar
  9. Tahawi Z, Orolinova N, Joshua IG, Bader M, Fletcher EC (2001) Altered vascular reactivity in arterioles of chronic intermittent hypoxic rats. J Appl Physiol 90:2007–2013, discussion 2000PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • Cécile A. Julien
    • 1
    Email author
  • Richard Kinkead
    • 1
  • Vincent Joseph
    • 1
    • 2
  • Aida Bairam
    • 1
  1. 1.Department of PediatricsLaval University, Centre de Recherche St-François d’Assise, Hôpital Saint-François d’AssiseQuébecCanada
  2. 2.CRCHUQ/Hop LavalQuébecCanada

Personalised recommendations