Neonatal Intermittent Hypoxia Induces Persistent Alteration of Baroreflex in Adult Male Rats

  • Cécile A. JulienEmail author
  • Richard Kinkead
  • Vincent Joseph
  • Aida Bairam
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 758)


Baroreflex is involved in the regulation of arterial blood pressure (BP). An increase in BP activates vagal inhibitory pathways to decrease heart rate; a concomitant decrease in sympathetic discharge reduces vascular resistance. Both responses reduce BP towards normal value. Conversely, a decrease in BP produces opposite effects to increase heart rate and vascular resistance.


Neonatal apnea Cardiovascular regulation 



We acknowledge Van Diep Doan for technical assistance, Melanie Pelletier, Sylvie Vigier, and Evelyne Vachon for animal care. Supported by grants from The Hospital for Sick Children’s Foundation/Canadian institute on Health Research (Grant #XG07-006), Réseau en Santé Respiratoire du FRSQ.


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Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • Cécile A. Julien
    • 1
    Email author
  • Richard Kinkead
    • 1
  • Vincent Joseph
    • 1
    • 2
  • Aida Bairam
    • 1
  1. 1.Department of PediatricsLaval University, Centre de Recherche St-François d’Assise, Hôpital Saint-François d’AssiseQuébecCanada
  2. 2.CRCHUQ/Hop LavalQuébecCanada

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