Neonatal Intermittent Hypoxia Induces Persistent Alteration of Baroreflex in Adult Male Rats
- 3.5k Downloads
Baroreflex is involved in the regulation of arterial blood pressure (BP). An increase in BP activates vagal inhibitory pathways to decrease heart rate; a concomitant decrease in sympathetic discharge reduces vascular resistance. Both responses reduce BP towards normal value. Conversely, a decrease in BP produces opposite effects to increase heart rate and vascular resistance.
KeywordsNeonatal apnea Cardiovascular regulation
We acknowledge Van Diep Doan for technical assistance, Melanie Pelletier, Sylvie Vigier, and Evelyne Vachon for animal care. Supported by grants from The Hospital for Sick Children’s Foundation/Canadian institute on Health Research (Grant #XG07-006), Réseau en Santé Respiratoire du FRSQ.
- Julien CA, Niane LM, Kinkead R, Bairam A, Joseph V (2010) Carotid sinus nerve stimulation, but not intermittent hypoxia, induces respiratory LTF in adult rats exposed to neonatal intermittent hypoxia. Am J Physiol Regul Integr Comp Physiol 299(1):R192–205Google Scholar