Advertisement

Interaction of Hypoxia and Core Temperature: Potential Role of TRPV1

  • Nathaniel Y. W. Yuen
  • Sandra G. Vincent
  • Brian Foo
  • John T. FisherEmail author
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 758)

Abstract

Hypoxia exposure in small mammals elicits an initial rise in ventilation followed by a reduction to levels that are often less than the normoxic value. The fall in ventilation is matched by a decrease in metabolism rate and a reduction in core body temperature (Tb). The transient receptor potential vanilloid 1 (TRPV1) ion channel has been implicated in thermoregulation (Caterina et al., Science 288:306–313, 2000) and recently shown to exert a tonic effect on Tb in human subjects (Gavva et al., Pain 136:202–210, 2008). We review herein the hypothesis that TRPV1 modulates the Tb response to hypoxia. We provide preliminary evidence that a 24 h hypoxia (FIO2=0.1) exposure caused an enhanced decrease in Tb in mutant TRPV1-/- mice compared to the TRPV1+/+ genotype (Tb was » 1°C lower than TRPV1+/+). Further investigation is warranted to determine the extent of TRPV1 ion channel involvement in acute and adaptive responses to hypoxia.

Keywords

Hypoxia TRPV1 Murine Thermoregulation 

References

  1. Barros RC, Zimmer ME, Branco LG, Milsom WK (2001) Hypoxic metabolic response of the golden-mantled ground squirrel. J Appl Physiol 91:603–612PubMedGoogle Scholar
  2. Bicego KC, Barros RC, Branco LG (2007) Physiology of temperature regulation: comparative aspects. Comp Biochem Physiol A Mol Integr Physiol 147:616–639PubMedCrossRefGoogle Scholar
  3. Brown R, Engel J (1973) Evidence for catecholamine involvement in the suppression of locomotor activity due to hypoxia. J Pharm Pharmacol 25:815–819PubMedCrossRefGoogle Scholar
  4. Caterina MJ (2007) Transient receptor potential ion channels as participants in thermosensation and thermoregulation. Am J Physiol Regul Integr Comp Physiol 292:R64–R76PubMedCrossRefGoogle Scholar
  5. Caterina MJ, Julius D (2001) The vanilloid receptor: a molecular gateway to the pain pathway. Annu Rev Neurosci 24:487–517PubMedCrossRefGoogle Scholar
  6. Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D (1997) The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389:816–824PubMedCrossRefGoogle Scholar
  7. Caterina MJ, Leffler A, Malmberg AB, Martin WJ, Trafton J, Petersen-Zeitz KR, Koltzenburg M, Basbaum AI, Julius D (2000) Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science 288:306–313PubMedCrossRefGoogle Scholar
  8. Clapham DE (2003) TRP channels as cellular sensors. Nature 426:517–524PubMedCrossRefGoogle Scholar
  9. Di Marzo V, Blumberg PM, Szallasi A (2002) Endovanilloid signaling in pain. Curr Opin Neurobiol 12:372–379PubMedCrossRefGoogle Scholar
  10. Donhoffer S, Szelenyi Z (1967) The role of brown adipose tissue in thermoregulatory heat production in the warm- and cold-adapted adult rat. Acta Physiol Acad Sci Hung 32:53–60PubMedGoogle Scholar
  11. Fisher JT (2009) The TRPV1 ion channel: implications for respiratory sensation and dyspnea. Respir Physiol Neurobiol 167:45–52PubMedCrossRefGoogle Scholar
  12. Frappell P, Lanthier C, Baudinette RV, Mortola JP (1992) Metabolism and ventilation in acute hypoxia: a comparative analysis in small mammalian species. Am J Physiol 262:R1040–R1046PubMedGoogle Scholar
  13. Gavva NR, Bannon AW, Surapaneni S, Hovland DN Jr, Lehto SG, Gore A, Juan T, Deng H, Han B, Klionsky L, Kuang R, Le A, Tamir R, Wang J, Youngblood B, Zhu D, Norman MH, Magal E, Treanor JJ, Louis JC (2007) The vanilloid receptor TRPV1 is tonically activated in vivo and involved in body temperature regulation. J Neurosci 27:3366–3374PubMedCrossRefGoogle Scholar
  14. Gavva NR, Treanor JJ, Garami A, Fang L, Surapaneni S, Akrami A, Alvarez F, Bak A, Darling M, Gore A, Jang GR, Kesslak JP, Ni L, Norman MH, Palluconi G, Rose MJ, Salfi M, Tan E, Romanovsky AA, Banfield C, Davar G (2008) Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans. Pain 136:202–210PubMedCrossRefGoogle Scholar
  15. Jia Y, Lee LY (2007) Role of TRPV receptors in respiratory diseases. Biochim Biophys Acta 1772:915–927PubMedCrossRefGoogle Scholar
  16. Jordt SE, Tominaga M, Julius D (2000) Acid potentiation of the capsaicin receptor determined by a key extracellular site. Proc Natl Acad Sci U S A 97:8134–8139PubMedCrossRefGoogle Scholar
  17. Julius D, Basbaum AI (2001) Molecular mechanisms of nociception. Nature 413:203–210PubMedCrossRefGoogle Scholar
  18. Lee LY, Gu Q (2009) Role of TRPV1 in inflammation-induced airway hypersensitivity. Curr Opin Pharmacol 9:243–249PubMedCrossRefGoogle Scholar
  19. Miller JA Jr, Miller FS (1966) Interactions between hypothermia and hypoxia-hypercapnia in neonates. Fed Proc 25:1338–1341PubMedGoogle Scholar
  20. Montell C (2005) The TRP superfamily of cation channels. Sci STKE 2005:re3PubMedCrossRefGoogle Scholar
  21. Mortola JP (2004) Implications of hypoxic hypometabolism during mammalian ontogenesis. Respir Physiol Neurobiol 141:345–356PubMedCrossRefGoogle Scholar
  22. Mortola JP (2005) Influence of temperature on metabolism and breathing during mammalian ontogenesis. Respir Physiol Neurobiol 149:155–164PubMedCrossRefGoogle Scholar
  23. Pedersen SF, Owsianik G, Nilius B (2005) TRP channels: an overview. Cell Calcium 38:233–252PubMedCrossRefGoogle Scholar
  24. Ristoiu V, Shibasaki K, Uchida K, Zhou Y, Ton BH, Flonta ML, Tominaga M (2011) Hypoxia-induced sensitization of transient receptor potential vanilloid 1 involves activation of hypoxia-inducible factor-1 alpha and PKC. Pain 152:936–945PubMedCrossRefGoogle Scholar
  25. Ross RA (2003) Anandamide and vanilloid TRPV1 receptors. Br J Pharmacol 140:790–801PubMedCrossRefGoogle Scholar
  26. Ruan T, Lin YS, Lin KS, Kou YR (2006) Mediator mechanisms involved in TRPV1 and P2X receptor-mediated, ROS-evoked bradypneic reflex in anesthetized rats. J Appl Physiol 101:644–654PubMedCrossRefGoogle Scholar
  27. Szallasi A, Blumberg PM (1999) Vanilloid (Capsaicin) receptors and mechanisms. Pharmacol Rev 51:159–212PubMedGoogle Scholar
  28. Teppema LJ, Dahan A (2010) The ventilatory response to hypoxia in mammals: mechanisms, measurement, and analysis. Physiol Rev 90:675–754PubMedCrossRefGoogle Scholar
  29. Van Der Stelt M, Di Mazoro V (2004) Endovanilloids. Putative endogenous ligands of transient receptor potential vanilloid 1 channels. Eur J Biochem 271:1827–1834CrossRefGoogle Scholar
  30. Vincent SG, Waddell AE, Caron MG, Walker JK, Fisher JT (2007) A murine model of hyperdopaminergic state displays altered respiratory control. FASEB J 21:1463–1471PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • Nathaniel Y. W. Yuen
    • 1
  • Sandra G. Vincent
    • 1
  • Brian Foo
    • 1
  • John T. Fisher
    • 2
    Email author
  1. 1.Department of Biomedical and Molecular SciencesQueen’s UniversityOntario, KingstonCanada
  2. 2.Departments of Biomedical and Molecular Sciences, Paediatrics, MedicineQueen’s UniversityOntario, KingstonCanada

Personalised recommendations