Abstract
The adipose tissue is one of the most vascularized tissues in the body. Both deposition and energy expenditure in the adipose tissues are dependent on appropriate vascular structures and functions that in their pathological settings may cause obesity and metabolic disorders. Emerging recent studies demonstrate that regulation of blood vessel functions in the adipose tissue by angiogenesis modulators significantly affects the size and metabolic status of adipose depots, suggesting that the adipose vasculature is an important target for the treatment of obesity and metabolic diseases. Additionally, angiogenesis modulators have been implied for the treatment of obesity- and diabetes-associated clinical disorders such as cancer, cardiovascular disease, ophthalmological disorders, and chronic ulcers. In this book chapter, we describe methodologies developed in our and other laboratories to study structural and functional aspects of the adipose vasculature in relation to the metabolic status of adipose depots.
Sharon Lim and Jennifer Honek contributed equally to this work.
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Acknowledgements
Y.C.’s laboratory is supported through research grants from the Swedish Research Council, the Swedish Cancer Foundation, the Karolinska Institute Foundation, the Karolinska Institute distinguished professor award, the Torsten Soderbergs foundation, the European Union Integrated Project of Metoxia (Project no. 222741) and the European Research Council (ERC) advanced grant ANGIOFAT (Project no 250021).
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Lim, S., Honek, J., Cao, Z., Seki, T., Xue, Y., Cao, Y. (2012). Quantitative Methods to Study Adipose Angiogenesis. In: Zudaire, E., Cuttitta, F. (eds) The Textbook of Angiogenesis and Lymphangiogenesis: Methods and Applications. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4581-0_5
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