Abstract
Intravital microscopy (IVM) is a powerful tool that has enabled imaging tumor progression and the modifications occurring within the surrounding tissue microenvironment in live animals. Here we describe the installation of an optical window in immunocompromised mice that allows performing longitudinal studies with minimal tissue interference. This approach provides detailed information on the dynamics of the interactions between blood vessels and implanted tumor cells.
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Acknowledgements
This research was supported by the Intramural Research Program of the NIH, National Institute of Dental and Craniofacial Research.
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© 2012 Springer Science+Business Media Dordrecht
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Amornphimoltham, P., Weigert, R. (2012). Intravital Imaging of Tumor-Initiated Angiogenesis Using a Dorsal Skin Chamber. In: Zudaire, E., Cuttitta, F. (eds) The Textbook of Angiogenesis and Lymphangiogenesis: Methods and Applications. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4581-0_21
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DOI: https://doi.org/10.1007/978-94-007-4581-0_21
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