Skip to main content
SpringerLink
Log in
Book cover

Respiratory Regulation - The Molecular Approach pp 229–237Cite as

Sarcoidosis and Tuberculosis: A Connection to the Human Leukocyte Antigen System

  • Conference paper
  • First Online:

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 756))

Abstract

Infectious, genetic factors, and autoimmunity have been considered as potential causes of sarcoidosis (SA). Pathological similarities between SA and tuberculosis (TB) suggest M. tuberculosis antigen(s) as causative agent(s). Our published comparative analysis of the human leukocyte antigens (HLA) system in patients with SA or TB in the same ethnic group revealed that some antigens were connected with high risk of developing of SA or TB, but other were comparable in both patient populations. Is it possible that the predominating occurrence of HLA antigens characteristic for TB may cause tuberculosis in patients with SA? To answer this question we evaluated the HLA class I and II alleles frequency by PCR amplification with sequence-specific primers in three women with histopathologically proven pulmonary SA, who developed bacteriologically confirmed TB on a corticosteroids (CS) therapy. Analysis of HLA in every case separately revealed a trend for higher occurrence of both alleles predisposing and protecting from TB than SA, in comparison with healthy individuals in our previously mentioned HLA genotyping study. Overall, the number of alleles predisposing to TB was statistically greater than the number of alleles connected with a high risk of developing SA. Also, the frequency of protecting alleles was statistically higher for TB than for SA. Therefore, SA in these patients developed at first, and the presence of additional environmental factors, e.g., age, CS might decrease an immune response and provoked TB. There is a possibility that the occurrence of HLA antigen more associated with high risk of developing TB than SA causes the development of tuberculosis in our patients with sarcoidosis.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  • American Thoracic Society. (1999). Statement on sarcoidosis. American Journal of Respiratory and Critical Care Medicine, 160, 736–755.

    Google Scholar 

  • Dubaniewicz, A. (2010). Mycobacterium tuberculosis heat shock proteins and autoimmunity in sarcoidosis. Autoimmunity Reviews, 9(6), 419–424.

    Article  PubMed  CAS  Google Scholar 

  • Dubaniewicz, A., & Dubaniewicz, A. (2005). Human Leukocyte antigens class I and class II: Associations and distribution in different ethnic groups of patients with pulmonary tuberculosis. Current Respiratory Medicine Reviews, 1(2), 117–121.

    Article  CAS  Google Scholar 

  • Dubaniewicz, A., Szczerkowska, Z., & Hoppe, A. (2003). Comparative analysis of HLA class I antigens in pulmonary sarcoidosis and tuberculosis in the same ethnic group. Mayo Clinic Proceedings, 78(4), 436–442.

    Article  PubMed  CAS  Google Scholar 

  • Dubaniewicz, A., Moszkowska, G., & Szczerkowska, Z. (2005). Frequency of DRB1-DQB1 two-locus haplotypes in tuberculosis: Preliminary report. Tuberculosis (Edinburgh, Scotland), 85, 259–267.

    Article  CAS  Google Scholar 

  • Dubaniewicz, A., Dubaniewicz-Wybieralska, M., Moszkowska, G., Sternau, A., & Dubaniewicz, A. (2006). Comparative analysis of DR and DQ alleles occurrence in sarcoidosis and tuberculosis in the same ethnic group: Preliminary study. Sarcoidosis, Vasculitis, and Diffuse Lung Diseases, 23(3), 180–189.

    PubMed  Google Scholar 

  • Goljan, A., Puscinska, E., Sankowska, M., & Zielinski, J. (2000). Polymorphism of histocompatibility class II antigens coded with the DRB gene in familial sarcoidosis in Poland. Pneumonologia i Alergologia Polska, 68(11–12), 533–544.

    PubMed  CAS  Google Scholar 

  • Grosser, M., Luther, T., Fuessel, M., Bickhardt, J., Magdolen, V., & Baretton, G. (2005). Clinical course of sarcoidosis in dependence on HLA-DRB1 allele frequencies, inflammatory markers, and the presence of M. tuberculosis DNA fragments. Sarcoidosis, Vasculitis, and Lung Diseases, 22(1), 66–74.

    Google Scholar 

  • Idali, F., Wiken, M., Wahlstrom, J., Mellstedt, H., Eklund, A., Rabbani, H., & Grunewald, J. (2006). Reduced Th1 response in the lungs of HLA-DRB1*0301 patients with pulmonary sarcoidosis. European Respiratory Journal, 27(3), 451–459.

    Article  PubMed  CAS  Google Scholar 

  • Khomenko, A. G., Litvinova, V. I., Chukanovaa, V. P., & Pospelova, L. E. (1990). Tuberculosis in patients with various HLA phenotypes. Tubercle, 71(3), 187–192.

    Article  PubMed  CAS  Google Scholar 

  • Kurian, S. M., Selvaraj, P., Reetha, A. M., Charles, N., & Narayanan, P. R. (2004). HLA-DR phenotypes and lymphocyte response to M. tuberculosis antigens in cures spinal tuberculosis patients and their contacts. The Indian Journal of Tuberculosis, 51, 71–75.

    Google Scholar 

  • Livnat, S., Madden, K. S., Felten, D. L., & Felten, S. Y. (1987). Regulation of the immune system by sympathetic neural mechanisms. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 11(2–3), 145–152.

    Article  CAS  Google Scholar 

  • Mach, F. (2002). Immunosuppressive effects of statins. Atherosclerosis Supplements, 3(1), 17–20.

    Article  PubMed  CAS  Google Scholar 

  • Messerli, F. H., & Grossman, E. (1998). The calcium antagonist controversy: A posthumous commentary. The American Journal of Cardiology, 82(9B), 35R–39R.

    Article  PubMed  CAS  Google Scholar 

  • Moller, D. R. (2007). Potential etiologic agents in sarcoidosis. Proceedings of the American Thoracic Society, 4(5), 465–468.

    Article  PubMed  Google Scholar 

  • Morgenthau, A. S., & Iannuzzi, M. C. (2011). Recent advances in sarcoidosis. Chest, 139(1), 174–182.

    Article  PubMed  Google Scholar 

  • Mrazek, F., Holla, L. I., Hutyrova, B., Znojil, V., Vasku, A., Kolek, V., Welsh, K. I., Vacha, J., du Bois, R. M., & Petrek, M. (2005). Association of tumor necrosis factor-α, lymphotoxin-α and HLA-DRB1 gene polymorphisms with Löfgren’s syndrome in Czech patients with sarcoidosis. Tissue Antigens, 65(2), 163–171.

    Article  PubMed  CAS  Google Scholar 

  • Olerup, O., & Zetterquist, H. (1991). HLA-DRB1*01 subtyping by allele-specific PCR amplification: A sensitive, specific and rapid technique. Tissue Antigens, 37(5), 197–204.

    Article  PubMed  CAS  Google Scholar 

  • Papadopoulos, K. I., Wassmuth, R., Sponsel, T., Sjöberg, K., & Hallengren, B. (2006). Sarcoidosis and autoimmunity: Evidence of differential associations with HLA class II markers. International Journal of Endocrinology and Metabolism, 4, 13–18.

    Google Scholar 

  • Plesner, A., Greenbaum, C. J., Gaur, L. K., Ernst, R. K., & Lernmark, A. (2002). Macrophages from high-risk HLA-DQB1*0201/*0302 type 1 diabetes mellitus patients are hypersensitive to lipopolysacharide stimulation. Scandinavian Journal of Immunology, 56(5), 522–529.

    Article  PubMed  CAS  Google Scholar 

  • Price, P., Witt, C., Allcock, R., Sayer, D., Garlepp, M., Kok, C. C., French, M., Mallal, S., & Christiansen, F. (1999). The genetic basis for the association of the 8.1 ancestral haplotype (A1,B8,DR3) with multiple immunopathological diseases. Immunology Reviews, 167, 257–274.

    Article  CAS  Google Scholar 

  • Sato, H., Woodhead, F. A., Ahmad, T., Grutters, J. C., Spagnolo, P., van den Bosch, J. M., Maier, L. A., Newman, L. S., Nagai, S., Izumi, T., Wells, A. U., du Bois, R. M., & Welsh, K. I. (2010). Sarcoidosis HLA class II genotyping distinguishes differences of clinical phenotype across ethnic groups. Human Molecular Genetics, 19(20), 4100–4111.

    Article  PubMed  CAS  Google Scholar 

  • Sidney, J., del Guercio, M. F., Southwood, S., & Sette, A. (2002). The HLA molecules DQA1*0501/B1*0201 and DQA1*0301/B1*0302 share an extensive overlap in peptide binding specificity. Journal of Immunology, 169(9), 5098–5108.

    Google Scholar 

  • Steffens, S., & Mach, F. (2004). Anti-inflammatory properties of statins. Seminars in Vascular Medicine, 4(4), 417–422.

    Article  PubMed  Google Scholar 

  • Swider, C., Schnittger, L., Bogunia-Kubik, K., Gerdes, J., Flad, H.-D., Lange, A., & Seitze, U. (1999). TNF-alpha and HLA-DR genotyping as potential prognostic markers in pulmonary sarcoidosis. European Cytokine Network, 10(2), 143–146.

    PubMed  CAS  Google Scholar 

  • Wahlstrom, J., Katchar, K., Wigzell, H., Olerup, O., Eklund, A., & Grunewald, J. (2001). Analysis of intracellular cytokines in CD4+ and CD8+ lung and blood T cells in sarcoidosis. American Journal of Respiratory and Critical Care Medicine, 163(1), 115–121.

    PubMed  CAS  Google Scholar 

  • Walzl, G., Ronacher, K., Hanekom, W., Scriba, T. J., & Zumla, A. (2011). Immunological biomarkers of tuberculosis. Nature Reviews Immunology, 11(5), 343–354.

    Article  PubMed  CAS  Google Scholar 

  • Yim, J. J., & Selvaraj, P. (2010). Genetic susceptibility in tuberculosis. Respirology, 15(2), 241–256.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pneumology, Gdansk Medical University, Debinki 7 St., Gdansk, Poland

    A. Dubaniewicz, M. Smigielska, K. Adamczyk-Bak, J. M. Slominski & P. Deeg

  2. Department of Nursing Management, Medical University of Gdansk, Gdansk, Poland

    A. Zimmermann

  3. Department of Radiology, Gdansk Medical University, Gdansk, Poland

    M. Dubaniewicz-Wybieralska

  4. Department of Clinical Immunology and Transplantology, Gdansk Medical University, Gdansk, Poland

    G. Moszkowska

  5. Department of Forensic Medicine, Gdansk Medical University, Gdansk, Poland

    J. Wysocka

  6. Deegenbergklinik Bad Kissingen Academic Teaching Hospital of the Julius Maximilians University in Würzburg, Bad Kissingen, Germany

    P. Deeg

Authors
  1. A. Dubaniewicz
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. Zimmermann
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. Smigielska
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. Dubaniewicz-Wybieralska
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. G. Moszkowska
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. J. Wysocka
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. K. Adamczyk-Bak
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. J. M. Slominski
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. P. Deeg
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A. Dubaniewicz .

Editor information

Editors and Affiliations

  1. Medical Research Center, Respiratory Research, Polish Academy of Sciences, Pawinskiego 5, Warsaw, 02-106, Poland

    Mieczyslaw Pokorski

Additional information

Conflicts of interest:  The authors declare no conflicts of interest in relation to this article.

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer Science+Business Media Dordrecht

About this paper

Cite this paper

Dubaniewicz, A. et al. (2013). Sarcoidosis and Tuberculosis: A Connection to the Human Leukocyte Antigen System. In: Pokorski, M. (eds) Respiratory Regulation - The Molecular Approach. Advances in Experimental Medicine and Biology, vol 756. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4549-0_29

Download citation

Publish with us

Policies and ethics

Search

Navigation