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Neutrophil Extracellular Trap in Human Diseases

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Respiratory Regulation - The Molecular Approach

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 756))

Abstract

NETosis is a unique death pathway that differs from apoptosis and necrosis and depends on the generation of reactive oxygen species (ROS) by NADPH oxidase. During this process, neutrophil extracellular traps (NETs) are created. NETs are extracellular structures composed of chromatin and variety of proteins from cells granules that bind and kill microorganisms. Recently, novel functions of NET have been proposed. It seems that neutrophil traps play an essential role during autoimmunity. They can induce and exacerbate diseases based on immune system malfunction.

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Authors and Affiliations

  1. Department of Laboratory Diagnostic and Clinical Immunology of Developmental Age, Warsaw Medical University, 24 Marszalkowska St, 00-576, Warsaw, Poland

    Magdalena Arazna, Michal P. Pruchniak & Urszula Demkow

  2. Department of Family Medicine, Internal and Metabolic Diseases, Warsaw Medical University, Systemic Vasculitis Outpatient Clinic, Czerniakowski Hospital, Warsaw, Poland

    Katarzyna Zycinska

Authors
  1. Magdalena Arazna
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  2. Michal P. Pruchniak
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  3. Katarzyna Zycinska
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  4. Urszula Demkow
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Correspondence to Magdalena Arazna .

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Editors and Affiliations

  1. Medical Research Center, Respiratory Research, Polish Academy of Sciences, Pawinskiego 5, Warsaw, 02-106, Poland

    Mieczyslaw Pokorski

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Conflicts of interest: The authors declare no conflicts of interest in relation to this article.

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Arazna, M., Pruchniak, M.P., Zycinska, K., Demkow, U. (2013). Neutrophil Extracellular Trap in Human Diseases. In: Pokorski, M. (eds) Respiratory Regulation - The Molecular Approach. Advances in Experimental Medicine and Biology, vol 756. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4549-0_1

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