Abstract
Differentiation between normal pressure hydrocephalus (NPH) and brain atrophy is difficult in clinical practice. The purpose of this paper was to apply two advanced statistical, pattern recognition methods: discriminant analysis (DA) and k-nearest neighbour (K-NN) for the classification of NPH and atrophy patients to approach computer aided differential diagnosis. The classification is based on a few measures of the center of foot pressure (COP) movements (radius, area, and length). The posturography method gives a measure of current postural stability by a quantitative evaluation of postural sways. Measurements have been performed in the standing upright position in two conditions: with eyes open (EO) and closed (EC). The study comprises 18 patients (mean age 64 ±13 years) diagnosed as normal pressure hydrocephalus and qualifying for shunt implantation. The patients were evaluated by static posturography twice: before and after surgery. The NPH patients were compared with 36 atrophy patients (mean age 64±13 years) and 47 healthy persons (mean age 60 ±7 years). There were two basic dissimilarities in the NPH patients before surgery in comparison with the other groups: very large sways and their independence from vision. Over 90% of the NPH cases both before and after surgery were correctly classified. There also were over 90% of correctly classified patients if we compared the before surgery NPH and atrophy patients. Further posturographic measurements and data collection are needed to verify these results.
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Acknowledgments
We would like to thank Adam Jozwik for releasing his K-NN software and valuable remarks. Support in part by the Biocentrum-Ochota project [POIG.02.03.00-00-003/09 – European Regional Development Fund, the Operational Program ‘Innovative Economy’ 2007–2013].
Conflicts of interest: The authors declare no conflicts of interest in relation to this article.
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Czerwosz, L., Szczepek, E., Sokolowska, B., Jurkiewicz, J., Czernicki, Z. (2013). Posturography in Differential Diagnosis of Normal Pressure Hydrocephalus and Brain Atrophy. In: Pokorski, M. (eds) Respiratory Regulation - Clinical Advances. Advances in Experimental Medicine and Biology, vol 755. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4546-9_40
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DOI: https://doi.org/10.1007/978-94-007-4546-9_40
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