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Small Changes, Big Effects: Chromatin Goes Aging

  • Asmitha Lazarus
  • Kushal Kr. Banerjee
  • Ullas Kolthur-SeetharamEmail author
Part of the Subcellular Biochemistry book series (SCBI, volume 61)

Abstract

Aging is a complex trait and is influenced by multiple factors that are both intrinsic and extrinsic to the organism (Kirkwood et al. 2000; Knight 2000). Efforts to understanding the mechanisms that extend or shorten lifespan have been made since the early twentieth century. Aging is characteristically associated with a progressive decline in the overall fitness of the organism. Several studies have provided valuable information about the molecular events that accompany this process and include accumulation of nuclear and mitochondrial mutations, shortened and dysfunctional telomeres, oxidative damage of protein/DNA, senescence and apoptosis (Muller 2009). Clinical studies and work on model organisms have shown that there is an increased susceptibility to conditions such as neurological disorders, diabetes, cardiovascular diseases, degenerative syndromes and even cancers, with age (Arvanitakis et al. 2006; Lee and Kim 2006; Rodriguez and Fraga 2010).

Keywords

Histone Modification Cellular Senescence Senescent Cell Lifespan Extension Werner Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Asmitha Lazarus
    • 1
  • Kushal Kr. Banerjee
    • 1
  • Ullas Kolthur-Seetharam
    • 1
    Email author
  1. 1.B-306, Department of Biological SciencesTata Institute of Fundamental ResearchColaba, MumbaiIndia

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