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Histone Acetylation as a Therapeutic Target

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Epigenetics: Development and Disease

Part of the book series: Subcellular Biochemistry ((SCBI,volume 61))

Abstract

The recent developments in the field of epigenetics have changed the way the covalent modifications were perceived from mere chemical tags to important biological recruiting platforms as well as decisive factors in the process of transcriptional regulation and gene expression. Over the years, the parallel investigations in the area of epigenetics and disease have also shown the significance of the epigenetic modifications as important regulatory nodes that exhibit dysfunction in disease states. In the present scenario where epigenetic therapy is also being considered at par with the conventional therapeutic strategies, this article reviews the role of histone acetylation as an epigenetic mark involved in different biological processes associated with normal as well as abnormal gene expression states, modulation of this acetylation by small molecules and warrants the possibility of acetylation as a therapeutic target.

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Acknowledgements

Work in our laboratory is supported by Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Department of Biotechnology, Government of India (Grant Nos. Grant/DBT/CSH/GIA/1752/2011-2012 and Chromatin and Disease: Programme Support Grant No. Grant/DBT/CSH/GIA/1957/2011-2012), Department of Science and Technology (DST) Government of India, Dabur Research Foundation and National Agricultural Innovative Project (NAIP), Indian Council of Agricultural Research, Govt. of India under component 4: Basic and Strategic Research (Grant No. NAIP/Comp-4/C-30017/2008-09). TKK is a recipient of Sir JC Bose national fellowship (DST, Government of India).

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  1. Transcription and Disease Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, P.O., Bangalore, 560 064, India

    B. Ruthrotha Selvi, Snehajyoti Chatterjee, Rahul Modak & Tapas K. Kundu

  2. MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK

    B. Ruthrotha Selvi

  3. Chemistry and Physics of Materials Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, P.O., Bangalore, 560 064, India

    M. Eswaramoorthy

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    Tapas K. Kundu

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Selvi, B.R., Chatterjee, S., Modak, R., Eswaramoorthy, M., Kundu, T.K. (2013). Histone Acetylation as a Therapeutic Target. In: Kundu, T. (eds) Epigenetics: Development and Disease. Subcellular Biochemistry, vol 61. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4525-4_25

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