Epigenetic Changes in Inflammatory and Autoimmune Diseases

  • Helene Myrtue Nielsen
  • Jörg TostEmail author
Part of the Subcellular Biochemistry book series (SCBI, volume 61)


In higher eukaryotic organisms epigenetic modifications are crucial for proper chromatin folding and thereby proper regulation of gene expression. In the last years the involvement of aberrant epigenetic modifications in inflammatory and autoimmune diseases has been recognized and attracted significant interest. However, the epigenetic mechanisms underlying the different disease phenotypes are still poorly understood. As autoimmune and inflammatory diseases are at least partly T cell mediated, we will provide in this chapter an introduction to the epigenetics of T cell differentiation followed by a summary of the current knowledge on aberrant epigenetic modifications that dysfunctional T cells display in various diseases such as type 1 diabetes, rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, inflammatory bowel disease, and asthma.


Systemic Lupus Erythematosus Patient Treg Cell HDAC Inhibitor Diesel Exhaust Particle Inflammatory Bowel Disease Pathogenesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  1. 1.Laboratory for Functional GenomicsFondation Jean Dausset – Centre d’Etude du Polymorphisme Humain (CEPH)ParisFrance
  2. 2.Laboratory for Epigenetics, Centre National de GénotypageCEA-Institut de GénomiqueEvryFrance

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