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Epigenetics: Development and Disease pp 319–341Cite as

Histone Variants and Transcription Regulation

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Part of the book series: Subcellular Biochemistry ((SCBI,volume 61))

Abstract

Histones are the protein components of chromatin and are important for its organization and compaction. Although core histones are exclusively expressed during S phase of the cell cycle, there exist variants of canonical histones that are expressed throughout the cell cycle. These histone variants are often deposited at defined regions of the genome and they play important roles in a variety of cellular processes, such as transcription regulation, heterochromatin formation and DNA repair. In this chapter, we will focus on several histone variants that have been linked to transcription regulation, and highlight their physical and functional features that facilitate their activities in this context.

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Authors and Affiliations

  1. Ontario Cancer Institute, 610 University Avenue, Toronto, ON, M5G 2M9, Canada

    Cindy Law & Peter Cheung

  2. Department of Medical Biophysics, University of Toronto, Toronto, ON, M5G 2M9, Canada

    Cindy Law & Peter Cheung

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  1. Cindy Law
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  2. Peter Cheung
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Correspondence to Peter Cheung .

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  1. Advanced Scientific Research, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for, Jakkur P.O., Bangalore, 560064, India

    Tapas K. Kundu

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Law, C., Cheung, P. (2013). Histone Variants and Transcription Regulation. In: Kundu, T. (eds) Epigenetics: Development and Disease. Subcellular Biochemistry, vol 61. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4525-4_14

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