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Application of Epiblast/Germ Line-Derived Very Small Embryonic-Like Stem Cells for Neurogenesis

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Stem Cells and Cancer Stem Cells, Volume 7

Part of the book series: Stem Cells and Cancer Stem Cells ((STEM,volume 7))

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Abstract

The population of pluripotent Oct-4+SSEA-1+Sca-1+Lin–CD45− very small embryonic/epiblast-like stem cells (VSELs) resides in murine adult bone marrow (BM) and in other tissues, including central nervous system (CNS). Similar population of very small Oct-4+SSEA-4+CD133+Lin-CD45− cells is also identified in human tissues. It has been proposed that VSELs play an important role in tissue/organ rejuvenation, which is supported by the fact that the number of these cells increases in peripheral blood (PB) both in mice and human during organ/tissue damage (e.g., stroke, heart infarct or skin burns). Thus, VSELs seem to be a mobile pool of pluripotent stem cells (PSCs) that shuttles between BM and peripheral tissues, including CNS, to supply stem cells for steady-state tissue turn-over or to replace damaged cells after organ injury. Our data suggest that VSELs could provide a therapeutic alternative to stem cells isolated from embryos and could be employed, for example, in the regeneration of damaged brain or spinal cord.

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Acknowledgment

This work was supported by NIH R01 DK074720, and the Henry M. and Stella M. Hoenig Endowment and EU Innovative Economy Operational Program POIG.01.01.01-00-109/09-01 and KBN grant (NN401 024536) to MZR and NIH P20RR018733 from the National Center for Research Resources to MK. C.L. was supported by FAPESP.

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Authors and Affiliations

  1. James Graham Brown Cancer Center, University of Louisville, 500 South Floyd Street, Louisville, KY, 40202, USA

    Claudiana Lameu, Magda Kucia & Mariusz Z. Ratajczak

  2. Department of Physiology, Pomeranian Medical University, 70-111, Szczecin, Poland

    Wojtek Marlicz & Przemyslaw Nowacki

Authors
  1. Wojtek Marlicz
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  2. Claudiana Lameu
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  3. Przemyslaw Nowacki
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  4. Magda Kucia
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  5. Mariusz Z. Ratajczak
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Editors and Affiliations

  1. Biology, Kean University, Union, New Jersey, USA

    M.A. Hayat

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Marlicz, W., Lameu, C., Nowacki, P., Kucia, M., Ratajczak, M.Z. (2012). Application of Epiblast/Germ Line-Derived Very Small Embryonic-Like Stem Cells for Neurogenesis. In: Hayat, M. (eds) Stem Cells and Cancer Stem Cells, Volume 7. Stem Cells and Cancer Stem Cells, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4285-7_25

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