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Midkine Is a Potential Therapeutic Target of Hepatocellular Carcinoma

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Book cover Midkine: From Embryogenesis to Pathogenesis and Therapy

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Abstract

Midkine (MK), a heparin-binding growth factor, has been demonstrated frequently and highly expressed in a variety of human carcinomas, including hepatocellular carcinoma (HCC). There is mounting evidence indicating that MK plays a significant role in carcinogenesis-related activities, such as proliferation, migration, anti-apoptosis, mitogenesis, transformation, and angiogenesis. Futhermore, siRNA, anti-sense oligonucleotides or antibody to MK has yielded great effects in anti-prolierative activities to HCC cells. Therefore, MK appears to be a potential molecular target for therapy of HCC.

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Author information

Authors and Affiliations

  1. Huzhou Key Laboratory of Molecular Medicine, Huzhou Central Hospital, Huzhou, Zhejiang Province, China

    Li Cheng Dai, Xing Yao & Jing Zhong

Authors
  1. Li Cheng Dai
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  2. Xing Yao
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  3. Jing Zhong
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Corresponding author

Correspondence to Li Cheng Dai .

Editor information

Editors and Affiliations

  1. Faculty of Medicine, Faculty of Biochemistry, Yeni Yüzyıl University, Yilanli Ayazma 26, Istanbul, 34000, Istanbul, Turkey

    Mine Ergüven

  2. , Department of Health Science, Aichi Gakuin University, 12 Araike, Iwasakicho, Nisshin, Aichi, Japan

    Takashi Muramatsu

  3. , Department of Histology and Embryology, Istanbul University Faculty of Medicine, Millet, Istanbul, Turkey

    Ayhan Bilir

Additional information

Funding: This work was financially supported by Key New Drug Discovery Project of 11th Five-Years Plan ( 2009ZX09103-680), the Ministry of Science and Technology of the People’s Republic of China.

Conflict of interest: We certify that there is no conflict of interest with any financial organization regarding the material discussed in the manuscript.

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© 2012 Springer Science+Business Media B.V.

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Dai, L.C., Yao, X., Zhong, J. (2012). Midkine Is a Potential Therapeutic Target of Hepatocellular Carcinoma. In: Ergüven, M., Muramatsu, T., Bilir, A. (eds) Midkine: From Embryogenesis to Pathogenesis and Therapy. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4234-5_24

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