Abstract
New multifunctional ion irradiation-based three-dimensional electronic structures are developed for biotechnological applications, specifically for sensing of biomaterials, bacteria and mammalian cells. This is accomplished by combined micrometric surface and nanometric bulk microstructuring of insulators (specifically of polymer foils and SiO2/Si hybride structures) by adequate ion beams. Our main goal is the production of a cheap small universal generic working platform with multifunctional properties for biomedical analysis. Surface engineering of this platform enables cell bonding and its bulk engineering enables the extraction of cell secrets, for the sake of intercepting and analyzing the biomolecules used in cell communication. The exact knowledge of the spectrum of these cell–secreted signalling molecules should enable one to identify unambiguously the cell type. This knowledge will help developing strategies for preventive quorum sensing of bacteria, with the aim of fighting bacterial infections in an ecologically secure way.
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Acknowledgement
L.A. acknowledges the support of the Edmond J. Safra Center for the Design and Engineering of Functional Biopolymers at Ben-Gurion University. D.F. thanks the Instituto de Fisica at the Universidade Federal do Rio Grande do Sul, Porto Alegre and the Universidad Autónoma Metropolitana, Iztapalapa, México City for his invitation as a guest researcher. We thank CAPES Brazilia and the Czech Grant Agency for support. We are further obliged to Prof. S. Cruz and O. Bukelman for valuable discussions and Dr. P. Apel from JNRI Dubna, Russia for providing us with the ion-irradiated foils.
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Fink, D. et al. (2012). Status and Perspectives of Ion Track Electronics for Advanced Biosensing. In: Shunin, Y., Kiv, A. (eds) Nanodevices and Nanomaterials for Ecological Security. NATO Science for Peace and Security Series B: Physics and Biophysics. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4119-5_24
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DOI: https://doi.org/10.1007/978-94-007-4119-5_24
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