Abstract
Statistical interactions and biological interactions are different concepts. Much confusion arises where the former is used to describe the latter, particularly in the exploration of gene-environment interactions. This will be illustrated and the circumstances under which statistical interaction may be legitimately interpreted for gene-environment interactions are presented. What is address, however, has relevance to all circumstances in biomedical research where statistical interaction is to be used and interpreted to infer biological meaning.
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Gilthorpe, M.S., Clayton, D.G. (2012). Statistical Interactions and Gene-Environment Joint Effects. In: Tu, YK., Greenwood, D. (eds) Modern Methods for Epidemiology. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-3024-3_17
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DOI: https://doi.org/10.1007/978-94-007-3024-3_17
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