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Phosphoinositides II: The Diverse Biological Functions pp 35–63Cite as

Phosphoinositide Signaling During Membrane Transport in Saccharomyces Cerevisiae

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Part of the book series: Subcellular Biochemistry ((SCBI,volume 59))

Abstract

Phosphatidylinositol (PI) is distinct from other phospholipids, possessing a head group that can be modified by phosphorylation at multiple positions to generate unique signaling molecules collectively known as phosphoinositides. The set of kinases and phosphatases that regulate PI metabolism are conserved throughout eukaryotic evolution, and numerous studies have demonstrated that phosphoinositides regulate a diverse spectrum of cellular processes, including vesicle transport, cell proliferation, and cytoskeleton organization. Over the past two decades, nearly all PI derivatives have been shown to interact directly with cellular proteins to affect their localization and/or activity. Additionally, there is growing evidence, which suggests that phosphoinositides may also affect local membrane topology. Here, we focus on the role of phosphoinositides in membrane trafficking and underscore the significant role that yeast has played in the field.

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  1. Department of Biomolecular Chemistry, University of Wisconsin-Madison Medical School, 1300 University Avenue, WI, 53706, Madison, USA

    Amber L. Schuh & Anjon Audhya

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  1. , NICHD, National Institutes of Health, Convent Drive 49, Bethesda, 20892-4480, Maryland, USA

    Tamas Balla

  2. , Cancer- and Immunobiology, University of Basel, Mattenstrasse 28, Basel, 4058, Switzerland

    Matthias Wymann

  3. , Pharmacology and Cancer Biology, Duke University Medical Center, Durham, 27710, North Carolina, USA

    John D. York

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Schuh, A.L., Audhya, A. (2012). Phosphoinositide Signaling During Membrane Transport in Saccharomyces Cerevisiae . In: Balla, T., Wymann, M., York, J. (eds) Phosphoinositides II: The Diverse Biological Functions. Subcellular Biochemistry, vol 59. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-3015-1_2

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