Differentiation of Human Pluripotent Stem Cells into Retinal Cells

  • Masha Idelson
  • Benjamin Reubinoff
Part of the Stem Cells and Cancer Stem Cells book series (STEM, volume 6)


Retinal and macular degeneration disorders are characterized by a progressive loss of photoreceptors, which causes visual impairment and blindness. In some cases, the visual loss is caused by dysfunction, degeneration and loss of underlying retinal pigment epithelial (RPE) cells and the subsequent death of photoreceptors. The grim reality is that there is no successful treatment for most of these blindness disorders. Cell therapy aimed at replenishing the degenerating cells is considered a potential therapeutic approach that may delay, halt or perhaps even reverse degeneration, as well as improve retinal function and prevent blindness in the aforementioned conditions. Human embryonic stem cells (hESC) and induced pluripotent stem cells (iPSCs) may serve as an unlimited donor source of photoreceptors and RPE cells for transplantation into degenerating retinas and for retinal disease modeling.


Retinal Pigment Epithelium Retinal Pigment Epithelium Cell Retinitis Pigmentosa Retinal Degeneration Neural Retina 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  1. 1.The Hadassah Human Embryonic Stem Cell Research Center, The Goldyne Savad Institute of Gene Therapy & The Department of Obstetrics and GynecologyHadassah University Medical CenterJerusalemIsrael

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