Human Embryonic Stem Cell Bank: Implication of Human Leukocyte Antigens and ABO Blood Group Antigens for Cell Transplantation

  • Jeoung Eun Lee
  • Myung Seo Kang
  • Dong Ryul LeeEmail author
Part of the Stem Cells and Cancer Stem Cells book series (STEM, volume 6)


Human embryonic stem cells (hESCs) are pluripotent and have an unlimited proliferation capacity; therefore, they have been expected as the most powerful candidate to have the potential for curing currently untreatable illnesses. For clinical applications, it is imperative that immune responses to transplanted hESCs and their derivatives should be prevented, although the safety of hESCs in terms of tumorigenicity and transmission of infection needs to be confirmed. Human has two major transplantation antigen systems, the Human leukocyte antigen (HLA) and ABO blood group antigen (ABO) system. HLA matching between the recipient and unrelated donors is the most important factor in improving outcomes in hematopoietic cell transplantation (HCT), and regarding solid organ transplantation, ABO matching is by far the most important factor. This review discusses the immunological barriers to cell transplantation therapy, the immunological properties of hESCs and their differentiated derivatives, and strategies for overcoming immune rejection after the transplantation of these cells. The creation of worldwide stem cell banks that are able to provide HLA-matched hESC-derived specific cells or tissues to patients would be the best strategy to overcome allograft rejection of hESCs, under the circumstances that the establishment of more than 1,000 hESC lines have been reported around the world.


Major Histocompatibility Complex Human Leukocyte Antigen Major Histocompatibility Complex Class Human Embryonic Stem Cell Hematopoietic Cell Transplantation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This research was supported by a grant (SC-1140) from the Stem Cell Research Center of the twenty-first Century Frontier Research Program funded by the Ministry of Education, Science and Technology, Republic of Korea.


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Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  • Jeoung Eun Lee
    • 1
  • Myung Seo Kang
    • 2
  • Dong Ryul Lee
    • 3
    Email author
  1. 1.CHA Stem Cell InstituteCHA UniversitySeoulSouth Korea
  2. 2.Department of Laboratory medicineCHA University College of MedicineSeoulSouth Korea
  3. 3.Department of Biomedical ScienceCHA UniversitySeoulSouth Korea

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