Advertisement

Human Embryonic Stem Cell Bank: Implication of Human Leukocyte Antigens and ABO Blood Group Antigens for Cell Transplantation

  • Jeoung Eun Lee
  • Myung Seo Kang
  • Dong Ryul Lee
Chapter
Part of the Stem Cells and Cancer Stem Cells book series (STEM, volume 6)

Abstract

Human embryonic stem cells (hESCs) are pluripotent and have an unlimited proliferation capacity; therefore, they have been expected as the most powerful candidate to have the potential for curing currently untreatable illnesses. For clinical applications, it is imperative that immune responses to transplanted hESCs and their derivatives should be prevented, although the safety of hESCs in terms of tumorigenicity and transmission of infection needs to be confirmed. Human has two major transplantation antigen systems, the Human leukocyte antigen (HLA) and ABO blood group antigen (ABO) system. HLA matching between the recipient and unrelated donors is the most important factor in improving outcomes in hematopoietic cell transplantation (HCT), and regarding solid organ transplantation, ABO matching is by far the most important factor. This review discusses the immunological barriers to cell transplantation therapy, the immunological properties of hESCs and their differentiated derivatives, and strategies for overcoming immune rejection after the transplantation of these cells. The creation of worldwide stem cell banks that are able to provide HLA-matched hESC-derived specific cells or tissues to patients would be the best strategy to overcome allograft rejection of hESCs, under the circumstances that the establishment of more than 1,000 hESC lines have been reported around the world.

Keywords

Major Histocompatibility Complex Human Leukocyte Antigen Major Histocompatibility Complex Class Human Embryonic Stem Cell Hematopoietic Cell Transplantation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgements

This research was supported by a grant (SC-1140) from the Stem Cell Research Center of the twenty-first Century Frontier Research Program funded by the Ministry of Education, Science and Technology, Republic of Korea.

References

  1. Akatsuka Y, Morishima Y, Kuzushima K, Kodera Y, Takahashi T (2007) Minor histocompatibility antigens as targets for immunotherapy using allogeneic immune reactions. Cancer Sci 98:1139–1146PubMedCrossRefGoogle Scholar
  2. Cabrera CM, Nieto A, Cortes JL, Montes RM, Catalina P, Cobo F, Barroso-Del-Jesus A, Concha A (2007) The low rate of HLA class I molecules on the human embryonic stem cell line HS293 is associated with the APM components’ expression level. Cell Biol Int 31:1072–1078PubMedCrossRefGoogle Scholar
  3. Drukker M (2008) Recent advancements towards the derivation of immune-compatible patient-specific human embryonic stem cell lines. Semin Immunol 20:123–129PubMedCrossRefGoogle Scholar
  4. Drukker M, Katz G, Urbach A, Schuldiner M, Markel G, Itskovitz-Eldor J, Reubinoff B, Mandelboim O, Benvenisty N (2002) Characterization of the expression of MHC proteins in human embryonic stem cells. Proc Natl Acad Sci USA 99:9864–9869PubMedCrossRefGoogle Scholar
  5. Drukker M, Katchman H, Katz G, Even-Tov Friedman S, Shezen E, Hornstein E, Mandelboim O, Reisner Y, Benvenisty N (2006) Human embryonic stem cells and their differentiated derivatives are less susceptible to immune rejection than adult cells. Stem Cells 24:221–229PubMedCrossRefGoogle Scholar
  6. Eapen M, Rubinstein P, Zhang MJ, Stevens C, Kurtzberg J, Scaradavou A, Loberiza FR, Champlin RE, Klein JP, Horowitz MM, Wagner JE (2007) Outcomes of transplantation of unrelated donor umbilical cord blood and bone marrow in children with acute leukaemia: a comparison study. Lancet 369:1947–1954PubMedCrossRefGoogle Scholar
  7. Fairchild PJ, Cartland S, Nolan KF, Waldmann H (2004) Embryonic stem cells and the challenge of transplantation tolerance. Trends Immunol 25:465–470PubMedCrossRefGoogle Scholar
  8. Grinnemo KH, Kumagai-Braesch M, Mansson-Broberg A, Skottman H, Hao X, Siddiqui A, Andersson A, Stromberg AM, Lahesmaa R, Hovatta O, Sylven C, Corbascio M, Dellgren G (2006) Human embryonic stem cells are immunogenic in allogeneic and xenogeneic settings. Reprod Biomed Online 13:712–724PubMedCrossRefGoogle Scholar
  9. Grinnemo KH, Sylven C, Hovatta O, Dellgren G, Corbascio M (2008) Immunogenicity of human embryonic stem cells. Cell Tissue Res 331:67–78PubMedCrossRefGoogle Scholar
  10. Helming AM, Brand A, Wolterbeek R, van Tol MJ, Egeler RM, Ball LM (2007) ABO incompatible stem cell transplantation in children does not influence outcome. Pediatr Blood Cancer 49:313–317PubMedCrossRefGoogle Scholar
  11. Lee SJ, Klein J, Haagenson M, Baxter-Lowe LA, Confer DL, Eapen M, Fernandez-Vina M, Flomenberg N, Horowitz M, Hurley CK, Noreen H, Oudshoorn M, Petersdorf E, Setterholm M, Spellman S, Weisdorf D, Williams TM, Anasetti C (2007) High-resolution donor-recipient HLA matching contributes to the success of unrelated donor marrow transplantation. Blood 110:4576–4583PubMedCrossRefGoogle Scholar
  12. Lee JE, Kang MS, Park MH, Shim SH, Yoon TK, Chung HM, Lee DR (2010) Evaluation of 28 human embryonic stem cell lines for use as unrelated donors in stem cell therapy: implications of HLA and ABO genotypes. Cell Transplant 19:1383–1395PubMedCrossRefGoogle Scholar
  13. Li L, Baroja ML, Majumdar A, Chadwick K, Rouleau A, Gallacher L, Ferber I, Lebkowski J, Martin T, Madrenas J, Bhatia M (2004) Human embryonic stem cells possess immune-privileged properties. Stem Cells 22:448–456PubMedCrossRefGoogle Scholar
  14. Lui KO, Waldmann H, Fairchild PJ (2009) Embryonic stem cells: overcoming the immunological barriers to cell replacement therapy. Curr Stem Cell Res Ther 4:70–80PubMedCrossRefGoogle Scholar
  15. Luong MX, Smith KP, Stein GS (2008) Human embryonic stem cell registries: value, challenges and opportunities. J Cell Biochem 105:625–632PubMedCrossRefGoogle Scholar
  16. Mölne J, Björquist P, Andersson K, Diswall M, Jeppsson A, Strokan V, Rydberg L, Breimer ME (2008) Blood group ABO antigen expression in human embryonic stem cells and in differentiated hepatocyte- and cardiomyocyte-like cells. Transplantation 27:1407–1413CrossRefGoogle Scholar
  17. Moreno-Gimeno I, Ledran MH, Lako M (2010) Hematopoietic differentiation from human ESCs as a model for developmental studies and future clinical translations. Invited review following the FEBS Anniversary Prize received on 5 July 2009 at the 34th FEBS Congress in Prague. FEBS J 277:5014–5025PubMedCrossRefGoogle Scholar
  18. Nakajima F, Tokunaga K, Nakatsuji N (2007) Human leukocyte antigen matching estimations in a hypothetical bank of human embryonic stem cell lines in the Japanese population for use in cell transplantation therapy. Stem Cells 25:983–985PubMedCrossRefGoogle Scholar
  19. O’Rourke PP, Abelman M, Heffernan KG (2008) Centralized banks for human embryonic stem cells: a worthwhile challenge. Cell Stem Cell 2:307–312PubMedCrossRefGoogle Scholar
  20. Paul LC, Baldwin WM 3rd (1987) Humoral rejection mechanisms and ABO incompatibility in renal transplantation. Transplant Proc 19:4463–4467PubMedGoogle Scholar
  21. Petersdorf EW (2008) Optimal HLA matching in hematopoietic cell transplantation. Curr Opin Immunol 20:588–593PubMedCrossRefGoogle Scholar
  22. Priddle H, Jones DR, Burridge PW, Patient R (2006) Hematopoiesis from human embryonic stem cells: overcoming the immune barrier in stem cell therapies. Stem Cells 24:815–824PubMedCrossRefGoogle Scholar
  23. Robertson NJ, Brook FA, Gardner RL, Cobbold SP, Waldmann H, Fairchild PJ (2007) Embryonic stem cell-derived tissues are immunogenic but their inherent immune privilege promotes the induction of tolerance. Proc Natl Acad Sci USA 104:20920–20925PubMedCrossRefGoogle Scholar
  24. Scherer MN, Banas B, Mantouvalou K, Schnitzbauer A, Obed A, Kramer BK, Schlitt HJ (2007) Current concepts and perspectives of immunosuppression in organ transplantation. Langenbecks Arch Surg 392:511–523PubMedCrossRefGoogle Scholar
  25. Senju S, Suemori H, Zembutsu H, Uemura Y, Hirata S, Fukuma D, Matsuyoshi H, Shimomura M, Haruta M, Fukushima S, Matsunaga Y, Katagiri T, Nakamura Y, Furuya M, Nakatsuji N, Nishimura Y (2007) Genetically manipulated human embryonic stem cell-derived dendritic cells with immune regulatory function. Stem Cells 25:2720–2729PubMedCrossRefGoogle Scholar
  26. Stussi G, Halter J, Schanz U, Seebach JD (2006) ABO-histo blood group incompatibility in hematopoietic stem cell and solid organ transplantation. Transfus Apher Sci 35:59–69PubMedCrossRefGoogle Scholar
  27. Swijnenburg RJ, Schrepfer S, Govaert JA, Cao F, Ransohoff K, Sheikh AY, Haddad M, Connolly AJ, Davis MM, Robbins RC, Wu JC (2008) Immunosuppressive therapy mitigates immunological rejection of human embryonic stem cell xenografts. Proc Natl Acad Sci USA 105:12991–12996PubMedCrossRefGoogle Scholar
  28. Takahashi K, Yamanaka S (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126:663–676PubMedCrossRefGoogle Scholar
  29. Taylor CJ, Bolton EM, Pocock S, Sharples LD, Pedersen RA, Bradley JA (2005) Banking on human embryonic stem cells: estimating the number of donor cell lines needed for HLA matching. Lancet 366:2019–2025PubMedCrossRefGoogle Scholar
  30. Tian X, Woll PS, Morris JK, Linehan JL, Kaufman DS (2006) Hematopoietic engraftment of human embryonic stem cell-derived cells is regulated by recipient innate immunity. Stem Cells 24:1370–1380PubMedCrossRefGoogle Scholar
  31. Tseng SY, Nishimoto KP, Silk KM, Majumdar AS, Dawes GN, Waldmann H, Fairchild PJ, Lebkowski JS, Reddy A (2009) Generation of immunogenic dendritic cells from human embryonic stem cells without serum and feeder cells. Regen Med 4:513–526PubMedCrossRefGoogle Scholar
  32. Verloes A, Van de Velde H, LeMaoult J, Mateizel I, Cauffman G, Horn PA, Carosella ED, Devroey P, De Waele M, Rebmann V, Vercammen M (2011) HLA-G expression in human embryonic stem cells and preimplantation embryos. J Immunol 186:2663–2671PubMedCrossRefGoogle Scholar
  33. Wang L, Menendez P, Shojaei F, Li L, Mazurier F, Dick JE, Cerdan C, Levac K, Bhatia M (2005) Generation of hematopoietic repopulating cells from human embryonic stem cells independent of ectopic HOXB4 expression. J Exp Med 201:1603–1614PubMedCrossRefGoogle Scholar
  34. Wekerle T, Sykes M (2001) Mixed chimerism and transplantation tolerance. Annu Rev Med 52:353–370PubMedCrossRefGoogle Scholar
  35. Zhan X, Dravid G, Ye Z, Hammond H, Shamblott M, Gearhart J, Cheng L (2004) Functional antigen-presenting leucocytes derived from human embryonic stem cells in vitro. Lancet 364:163–171PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  • Jeoung Eun Lee
    • 1
  • Myung Seo Kang
    • 2
  • Dong Ryul Lee
    • 3
  1. 1.CHA Stem Cell InstituteCHA UniversitySeoulSouth Korea
  2. 2.Department of Laboratory medicineCHA University College of MedicineSeoulSouth Korea
  3. 3.Department of Biomedical ScienceCHA UniversitySeoulSouth Korea

Personalised recommendations