Derivation and Invasive Function of Trophoblast from Human Pluripotent Stem Cells

  • Harry MooreEmail author
  • Ramya Udayashankar
Part of the Stem Cells and Cancer Stem Cells book series (STEM, volume 6)


Human embryo implantation in situ remains a ‘blackbox’ as it is virtually inaccessible to investigation. The finding that pluripotent stem cells such as human embryonic stem cells and induced pluripotent stem cells generate trophoblast has created a new paradigm for studying the very earliest stages of human development in vitro. The phenotype of trophoblast cells generated from pluripotent stem cells depends on the specific culture conditions and displays considerable variation with some uncertainty. These derived cells offer an important new route to investigate the earliest stages of human trophoblast differentiation and in co-culture with endometrial cells an in vitro model of embryo invasiveness at implantation.


Trophoblast Cell Human Pluripotent Stem Cell Cytotrophoblast Cell Trophoblast Stem Trophoblast Differentiation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  1. 1.Centre for Stem Cell BiologyUniversity of SheffieldSheffieldUK
  2. 2.GE Healthcare Life sciencesCardiffUK

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