Derivation and Invasive Function of Trophoblast from Human Pluripotent Stem Cells
Human embryo implantation in situ remains a ‘blackbox’ as it is virtually inaccessible to investigation. The finding that pluripotent stem cells such as human embryonic stem cells and induced pluripotent stem cells generate trophoblast has created a new paradigm for studying the very earliest stages of human development in vitro. The phenotype of trophoblast cells generated from pluripotent stem cells depends on the specific culture conditions and displays considerable variation with some uncertainty. These derived cells offer an important new route to investigate the earliest stages of human trophoblast differentiation and in co-culture with endometrial cells an in vitro model of embryo invasiveness at implantation.
KeywordsTrophoblast Cell Human Pluripotent Stem Cell Cytotrophoblast Cell Trophoblast Stem Trophoblast Differentiation
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