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Propagation of Human Embryonic Stem Cells: Role of TGF β

  • Prasad Pethe
  • Deepa Bhartiya
Chapter
Part of the Stem Cells and Cancer Stem Cells book series (STEM, volume 6)

Abstract

Human embryonic stem cells (hES) have tremendous application in several areas of research including regenerative medicine, developmental biology, drug screening, and drug discovery. Transforming Growth Factor (TGF) β and its family of proteins have an indispensible role in genesis and maintenance of various organs and cancer and are also used for the propagation of embryonic stem cells. In this review, we discuss the TGF β family members, and their signalling, and delve into the molecular mechanism by which TGF β proteins may regulate the propagation of human embryonic stem cells.

Keywords

Embryonic Stem Cell Transform Growth Factor Human Embryonic Stem Cell Smad Protein Define Culture Medium 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  1. 1.Stem Cell Biology DepartmentNational Institute for Research in Reproductive HealthMumbaiIndia

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