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Pediatric Cancer, Volume 2 pp 129–141Cite as

Immunohistochemistry in the Differential Diagnosis of Adult and Pediatric Brain Tumors

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Part of the book series: Pediatric Cancer ((PECA,volume 2))

Abstract

Immunohistochemical stains are of increasing importance in evaluating adult and pediatric intracranial neoplasms. Surgical neuropathologists frequently utilize these in the subclassification and characterization of CNS neoplasms, assessment of prognosis, identification of therapeutic targets, and possibly helping predict response to therapy. Here, we review existing and novel antibodies that are of immediate utility in the differential diagnosis of adult and pediatric CNS neoplasms. The discussion focuses on the role of various immunostains in differentiating non-neoplastic brain from glioma, in subtyping glial and non-glial tumors, and in providing clinically relevant prognostic and predictive information.

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Authors and Affiliations

  1. The Methodist Hospital & University of Texas M.D. Anderson Cancer Center, Houston, TX, USA

    Aditya Raghunathan

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  1. Aditya Raghunathan
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Correspondence to Aditya Raghunathan .

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Editors and Affiliations

  1. , Kean University, Room 213, Library building, Morris Avenue 1000, Union, 07083, New Jersey, USA

    M.A. Hayat

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Raghunathan, A. (2012). Immunohistochemistry in the Differential Diagnosis of Adult and Pediatric Brain Tumors. In: Hayat, M. (eds) Pediatric Cancer, Volume 2. Pediatric Cancer, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2957-5_13

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