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Central Nervous System Imaging in Childhood Leukemia

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Book cover Pediatric Cancer, Volume 2

Part of the book series: Pediatric Cancer ((PECA,volume 2))

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Abstract

The imaging of CNS has been increasingly recognized in pediatric oncology as a complex area. Imaging has increased our ability to diagnose CNS manifestations and treatment complications in childhood leukemia. Compared to conventional imaging, advanced MR modalities provide deeper insight into pathophysiology and pathobiochemistry of the CNS involvement in pediatric oncologic diseases. This is important because survivors of childhood leukemia are at risk of developing therapy-induced secondary neurological impairments and/or secondary tumors, even after many years. For a systematic approach we have divided the CNS imaging into manifestations of leukemia and side effects of the therapeutic procedures. Under CNS manifestations of the primary disease we understand the leptomeningeal or parenchymal manifestations, as well as the involvement of intracranial vessels. The side effects of the therapeutic procedures may include cerebrovascular disorders, white matter lesions, infections, atrophy and the most threatening of all, secondary tumors. Complications, such as cerebrovascular disorders, can be due either to disease itself or can be secondary to its treatment.

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Authors and Affiliations

  1. Institut für Neuroradiologie, Klinikum der Johann Wolfgang Goethe-Universität, Schleusenweg 2-16, D-60528, Frankfurt am Main, Germany

    Luciana Porto & Heinrich Lanfermann

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  1. Luciana Porto
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  2. Heinrich Lanfermann
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Correspondence to Luciana Porto .

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  1. , Kean University, Room 213, Library building, Morris Avenue 1000, Union, 07083, New Jersey, USA

    M.A. Hayat

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Porto, L., Lanfermann, H. (2012). Central Nervous System Imaging in Childhood Leukemia. In: Hayat, M. (eds) Pediatric Cancer, Volume 2. Pediatric Cancer, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2957-5_12

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