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Stem Cells and Cancer Stem Cells, Volume 5 pp 85–91Cite as

Role of Neuropeptide Y on the Maintenance of Self-renewal and Proliferation of Human Embryonic Stem Cells

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Part of the book series: Stem Cells and Cancer Stem Cells ((STEM,volume 5))

Abstract

Pluripotent human embryonic stem cells (hESCs) have the capacity to proliferate indefinitely and to differentiate into almost all cell types derived from the three germ layers in vitro. Thus, they are considered to be a promising unlimited source of cells for regenerative medicine and drug discovery. Currently, the development of a serum-free, xeno-free medium that supports the derivation, large-scale propagation and long-term culture of hESCs has become one of the key challenges in translating hESCs into various applications. A detailed understanding of the signaling network that controls hESC self-renewal and proliferation is essential for the development of a fully defined, clinical-grade hESC culture system. Here, we highlight the role of neuropeptide Y (NPY) signaling in the maintenance of self-renewal and proliferation of hESCs.

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Authors and Affiliations

  1. Regenerative Medicine Research Center, KRIBB, 125 Gwahak-ro, Yuseong-gu, Daejeon, 305-806, South Korea

    Mi-Young Son & Yee Sook Cho

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  1. Mi-Young Son
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  2. Yee Sook Cho
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Correspondence to Yee Sook Cho .

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  1. , Kean University, Room 213, Library building, Morris Avenue 1000, Union, 07083, New Jersey, USA

    M.A. Hayat

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Son, MY., Cho, Y.S. (2012). Role of Neuropeptide Y on the Maintenance of Self-renewal and Proliferation of Human Embryonic Stem Cells. In: Hayat, M. (eds) Stem Cells and Cancer Stem Cells, Volume 5. Stem Cells and Cancer Stem Cells, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2900-1_8

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