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Stem Cells and Cancer Stem Cells, Volume 5 pp 73–83Cite as

Mesenchymal Stem Cell Treatment for Ischemic Brain Injury

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Part of the book series: Stem Cells and Cancer Stem Cells ((STEM,volume 5))

Abstract

Cell-based therapies for experimental models of neonatal and adult ischemic brain injury are effective for repairing the damaged brain. Transplantation of mesenchymal stem cells does not only replace lost tissue, but more importantly also enhances repair processes in the brain. The induction of processes like neurogenesis, angiogenesis and axonal remodeling likely underlie the improved functional outcome. These repair processes are mediated via many growth factors secreted by transplanted stem cells and parenchymal cells. After transplantation, mesenchymal stem cells react to the ischemic cerebral environment and change their secretory profile to the need of the cerebral environment. The interplay between transplanted mesenchymal stem cells and parenchymal cells will ultimately define the extent of repair.

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Authors and Affiliations

  1. Laboratory for Neuroimmunology and Developmental Origins of Disease (NIDOD), University Medical Center Utrecht, Wilhelmina’s Children Hospital, Room KC 03.068.0, Lundlaan 6, 3584 EA, Utrecht, The Netherlands

    Cindy T. J. van Velthoven, Annemieke Kavelaars & Cobi J. Heijnen

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  1. Cindy T. J. van Velthoven
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  2. Annemieke Kavelaars
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  3. Cobi J. Heijnen
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Corresponding author

Correspondence to Cindy T. J. van Velthoven .

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Editors and Affiliations

  1. , Kean University, Room 213, Library building, Morris Avenue 1000, Union, 07083, New Jersey, USA

    M.A. Hayat

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van Velthoven, C.T.J., Kavelaars, A., Heijnen, C.J. (2012). Mesenchymal Stem Cell Treatment for Ischemic Brain Injury. In: Hayat, M. (eds) Stem Cells and Cancer Stem Cells, Volume 5. Stem Cells and Cancer Stem Cells, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2900-1_7

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